ID  Q96A49;
PN  Synapse-associated protein 1;
GN  SYAP1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9D5V6}. Golgi apparatus {ECO:0000250|UniProtKB:Q9D5V6}. Perikaryon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, axon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D5V6}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Membrane {ECO:0000269|PubMed:23300339}. Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (By similarity). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (PubMed:23300339). {ECO:0000250|UniProtKB:Q9D5V6, ECO:0000269|PubMed:23300339}.
DR  UNIPROT: Q96A49;
DR  UNIPROT: Q68CP1;
DR  UNIPROT: Q96C60;
DR  UNIPROT: Q96JQ6;
DR  UNIPROT: Q96T20;
DR  PDB: 1X3A;
DR  Pfam: PF03909;
DR  PROSITE: PS50858;
DE  Function: Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.
DE  Reference Proteome: Yes;
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: Q6ZMQ8; IntAct: EBI-32723474; Score: 0.27
DE  Interaction: Q16659; IntAct: EBI-12502733; Score: 0.35
DE  Interaction: Q96FW1; IntAct: EBI-10770198; Score: 0.35
DE  Interaction: Q9CS74; IntAct: EBI-11150651; Score: 0.35
DE  Interaction: Q9P0N5; IntAct: EBI-11398030; Score: 0.27
DE  Interaction: Q9NUX5; IntAct: EBI-11304963; Score: 0.51
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: P10827; IntAct: EBI-24380444; Score: 0.56
DE  Interaction: O14798; IntAct: EBI-24707651; Score: 0.56
DE  Interaction: P30301; IntAct: EBI-24712218; Score: 0.56
DE  Interaction: O95159; IntAct: EBI-24729358; Score: 0.56
DE  Interaction: Q15848; IntAct: EBI-24739002; Score: 0.56
DE  Interaction: Q8WVK2; IntAct: EBI-21500567; Score: 0.35
DE  Interaction: P02675; IntAct: EBI-21646531; Score: 0.35
DE  Interaction: P05120; IntAct: EBI-21713063; Score: 0.35
DE  Interaction: P59536; IntAct: EBI-21736177; Score: 0.35
DE  Interaction: Q96K76; IntAct: EBI-21756437; Score: 0.35
DE  Interaction: Q9NY26; IntAct: EBI-21772441; Score: 0.35
DE  Interaction: P04798; IntAct: EBI-21774067; Score: 0.35
DE  Interaction: Q13526; IntAct: EBI-21884604; Score: 0.40
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: Q96I36; IntAct: EBI-16791250; Score: 0.27
DE  Interaction: P15311; IntAct: EBI-16791848; Score: 0.27
DE  Interaction: O14880; IntAct: EBI-16796348; Score: 0.27
DE  Interaction: Q9HBL7; IntAct: EBI-16797429; Score: 0.27
DE  Interaction: O75880; IntAct: EBI-16799233; Score: 0.27
DE  Interaction: Q9H9B4; IntAct: EBI-16799442; Score: 0.27
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: Q9NS69; IntAct: EBI-16802054; Score: 0.27
DE  Interaction: Q9C0B5; IntAct: EBI-25637382; Score: 0.35
DE  Interaction: Q2TAZ0; IntAct: EBI-26443127; Score: 0.35
DE  Interaction: Q99608; IntAct: EBI-26955093; Score: 0.47
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: Q9UM73; IntAct: EBI-32719830; Score: 0.27
DE  Interaction: P29322; IntAct: EBI-32721175; Score: 0.27
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
DE  Interaction: P22607; IntAct: EBI-32721979; Score: 0.27
DE  Interaction: P22455; IntAct: EBI-32722168; Score: 0.27
DE  Interaction: P08069; IntAct: EBI-32722947; Score: 0.27
DE  Interaction: P06213; IntAct: EBI-32723092; Score: 0.27
DE  Interaction: Q06124; IntAct: EBI-32723738; Score: 0.27
DE  Interaction: Q16288; IntAct: EBI-32724526; Score: 0.27
DE  Interaction: P07949; IntAct: EBI-32725031; Score: 0.27
GO  GO:0070161;
GO  GO:0030424;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0070062;
GO  GO:0031234;
GO  GO:0005794;
GO  GO:0030426;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0045211;
GO  GO:0042734;
GO  GO:0045202;
GO  GO:0030154;
GO  GO:0071364;
GO  GO:0032869;
GO  GO:1990314;
GO  GO:0036120;
GO  GO:0045600;
GO  GO:0071902;
GO  GO:0048172;
GO  GO:0038203;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFRGLSSWLGLQQPVAGGGQPNGDAPPEQPSETVAESAEEELQQAGDQELLHQAKDFGNYLFNFASAATKKITESVAETA
SQ  QTIKKSVEEGKIDGIIDKTIIGDFQKEQKKFVEEQHTKKSEAAVPPWVDTNDEETIQQQILALSADKRNFLRDPPAGVQF
SQ  NFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRVSLIKQSAQLTALAAQQQAAGKEEKSNGREQDLPL
SQ  AEAVRPKTPPVVIKSQLKTQEDEEEISTSPGVSEFVSDAFDACNLNQEDLRKEMEQLVLDKKQEETAVLEEDSADWEKEL
SQ  QQELQEYEVVTESEKRDENWDKEIEKMLQEEN
//