ID  Q96AG4;
PN  Leucine-rich repeat-containing protein 59, N-terminally processed;
GN  LRRC59;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.
DR  UNIPROT: Q96AG4;
DR  UNIPROT: B2RE83;
DR  UNIPROT: D3DTX8;
DR  UNIPROT: Q9P189;
DR  Pfam: PF13855;
DR  PROSITE: PS51450;
DR  OMIM: 614854;
DR  DisGeNET: 55379;
DE  Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}.
DE  Reference Proteome: Yes;
DE  Interaction: P00519; IntAct: EBI-10101379; Score: 0.35
DE  Interaction: P00533; IntAct: EBI-702075; Score: 0.35
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: P12931; IntAct: EBI-25384369; Score: 0.35
DE  Interaction: Q15125; IntAct: EBI-24548327; Score: 0.56
DE  Interaction: Q5BJF2; IntAct: EBI-24560640; Score: 0.56
DE  Interaction: P19438; IntAct: EBI-364474; Score: 0.00
DE  Interaction: P40337; IntAct: EBI-1061500; Score: 0.00
DE  Interaction: P78396; IntAct: EBI-1065388; Score: 0.00
DE  Interaction: P23508; IntAct: EBI-1066087; Score: 0.00
DE  Interaction: Q9UET6; IntAct: EBI-1069061; Score: 0.00
DE  Interaction: Q9H1Y0; IntAct: EBI-1070756; Score: 0.00
DE  Interaction: P56537; IntAct: EBI-1071348; Score: 0.00
DE  Interaction: Q9UKE5; IntAct: EBI-1073298; Score: 0.00
DE  Interaction: Q14164; IntAct: EBI-1075053; Score: 0.00
DE  Interaction: P11171; IntAct: EBI-1076336; Score: 0.00
DE  Interaction: O75815; IntAct: EBI-1077503; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-1078796; Score: 0.00
DE  Interaction: Q9Y478; IntAct: EBI-1079493; Score: 0.00
DE  Interaction: P01889; IntAct: EBI-1083352; Score: 0.00
DE  Interaction: P29372; IntAct: EBI-1084066; Score: 0.00
DE  Interaction: P48039; IntAct: EBI-1188258; Score: 0.53
DE  Interaction: Q9UL18; IntAct: EBI-7641579; Score: 0.35
DE  Interaction: Q9Y2K6; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P01100; IntAct: EBI-2687467; Score: 0.00
DE  Interaction: Q92731; IntAct: EBI-2880211; Score: 0.46
DE  Interaction: Q9Y371; IntAct: EBI-3622855; Score: 0.35
DE  Interaction: P51858; IntAct: EBI-4409719; Score: 0.35
DE  Interaction: P68400; IntAct: EBI-5321978; Score: 0.44
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: P19320; IntAct: EBI-6189915; Score: 0.35
DE  Interaction: P02751; IntAct: EBI-6285956; Score: 0.35
DE  Interaction: Q86VP6; IntAct: EBI-21322532; Score: 0.35
DE  Interaction: P67809; IntAct: EBI-8853354; Score: 0.56
DE  Interaction: P57078; IntAct: EBI-12503575; Score: 0.35
DE  Interaction: P10398; IntAct: EBI-10101513; Score: 0.35
DE  Interaction: O60307; IntAct: EBI-10103761; Score: 0.35
DE  Interaction: Q96FW1; IntAct: EBI-10770198; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: P06461; IntAct: EBI-11723785; Score: 0.35
DE  Interaction: Q9JLQ0; IntAct: EBI-11033702; Score: 0.35
DE  Interaction: P35749; IntAct: EBI-11098041; Score: 0.35
DE  Interaction: Q9NPD3; IntAct: EBI-11126463; Score: 0.35
DE  Interaction: Q15006; IntAct: EBI-11130215; Score: 0.35
DE  Interaction: Q9NVD3; IntAct: EBI-11154093; Score: 0.35
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q96GX1; IntAct: EBI-11375285; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: Q96Q45; IntAct: EBI-11396533; Score: 0.27
DE  Interaction: Q99IB8; IntAct: EBI-11422269; Score: 0.35
DE  Interaction: Q9H2L4; IntAct: EBI-24519719; Score: 0.56
DE  Interaction: Q9H0R3; IntAct: EBI-24521426; Score: 0.56
DE  Interaction: Q96MX0; IntAct: EBI-24523693; Score: 0.56
DE  Interaction: Q6UX34; IntAct: EBI-24629651; Score: 0.56
DE  Interaction: P55061; IntAct: EBI-24424978; Score: 0.56
DE  Interaction: Q5VZY2; IntAct: EBI-24537950; Score: 0.56
DE  Interaction: P56851; IntAct: EBI-24543931; Score: 0.56
DE  Interaction: Q5TGU0; IntAct: EBI-24553760; Score: 0.56
DE  Interaction: O95406; IntAct: EBI-24558366; Score: 0.56
DE  Interaction: Q6RW13; IntAct: EBI-24562799; Score: 0.56
DE  Interaction: Q96DZ9; IntAct: EBI-24576076; Score: 0.56
DE  Interaction: Q9ULP0; IntAct: EBI-24580735; Score: 0.56
DE  Interaction: Q8N609; IntAct: EBI-24593407; Score: 0.56
DE  Interaction: P29972; IntAct: EBI-24603065; Score: 0.56
DE  Interaction: P56945; IntAct: EBI-15099384; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q12797; IntAct: EBI-21649522; Score: 0.35
DE  Interaction: Q14684; IntAct: EBI-16685608; Score: 0.35
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.42
DE  Interaction: P11279; IntAct: EBI-16794808; Score: 0.27
DE  Interaction: P08559; IntAct: EBI-20306509; Score: 0.35
DE  Interaction: Q9HCE5; IntAct: EBI-20595531; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-20821761; Score: 0.35
DE  Interaction: O95819; IntAct: EBI-20900495; Score: 0.40
DE  Interaction: Q00765; IntAct: EBI-20901832; Score: 0.40
DE  Interaction: Q9Y5A6; IntAct: EBI-20903696; Score: 0.40
DE  Interaction: O76021; IntAct: EBI-20906176; Score: 0.40
DE  Interaction: P62917; IntAct: EBI-20907960; Score: 0.40
DE  Interaction: Q9UL63; IntAct: EBI-20908464; Score: 0.40
DE  Interaction: B3KS81; IntAct: EBI-20908696; Score: 0.40
DE  Interaction: Q9Y3D0; IntAct: EBI-20909184; Score: 0.40
DE  Interaction: Q15648; IntAct: EBI-20910000; Score: 0.40
DE  Interaction: Q8ND76; IntAct: EBI-20923706; Score: 0.40
DE  Interaction: Q9UPN4; IntAct: EBI-20923938; Score: 0.40
DE  Interaction: Q5VUA4; IntAct: EBI-20932048; Score: 0.40
DE  Interaction: Q9ULD8; IntAct: EBI-20933132; Score: 0.40
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q15077; IntAct: EBI-21262943; Score: 0.35
DE  Interaction: F5H1C8; IntAct: EBI-21264930; Score: 0.35
DE  Interaction: Q9H1C4; IntAct: EBI-21266770; Score: 0.35
DE  Interaction: P12004; IntAct: EBI-21236980; Score: 0.37
DE  Interaction: Q00059; IntAct: EBI-21980665; Score: 0.35
DE  Interaction: Q04837; IntAct: EBI-21980936; Score: 0.35
DE  Interaction: O15530; IntAct: EBI-25375702; Score: 0.35
DE  Interaction: O84008; IntAct: EBI-22302433; Score: 0.35
DE  Interaction: P0DJI4; IntAct: EBI-22303808; Score: 0.35
DE  Interaction: Q8NF50; IntAct: EBI-25409278; Score: 0.35
DE  Interaction: Q6ZRI8; IntAct: EBI-25410669; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: Q8NHP6; IntAct: EBI-25617558; Score: 0.35
DE  Interaction: P60033; IntAct: EBI-25645944; Score: 0.35
DE  Interaction: Q8NBM4; IntAct: EBI-25771384; Score: 0.35
DE  Interaction: Q53F19; IntAct: EBI-26396827; Score: 0.35
DE  Interaction: Q8TB24; IntAct: EBI-26518569; Score: 0.35
DE  Interaction: Q8NDZ4; IntAct: EBI-26597064; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: Q13363; IntAct: EBI-27044482; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: A0A0H3NFP4; IntAct: EBI-27055788; Score: 0.27
DE  Interaction: A0A0H3NG92; IntAct: EBI-27055968; Score: 0.27
DE  Interaction: A0A0H3NF08; IntAct: EBI-27055973; Score: 0.27
DE  Interaction: A0A0H3NJM6; IntAct: EBI-27055978; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
DE  Interaction: P13569; IntAct: EBI-27087549; Score: 0.35
DE  Interaction: O60285; IntAct: EBI-28931176; Score: 0.35
DE  Interaction: P04049; IntAct: EBI-28931531; Score: 0.35
DE  Interaction: P20794; IntAct: EBI-28934658; Score: 0.35
DE  Interaction: P32298; IntAct: EBI-28934990; Score: 0.35
DE  Interaction: P36507; IntAct: EBI-28935019; Score: 0.35
DE  Interaction: Q86V86; IntAct: EBI-28942203; Score: 0.35
DE  Interaction: Q8NI60; IntAct: EBI-28943519; Score: 0.35
DE  Interaction: Q9UPE1; IntAct: EBI-28946981; Score: 0.35
DE  Interaction: Q9UIH9; IntAct: EBI-29019642; Score: 0.35
DE  Interaction: Q9BXK1; IntAct: EBI-29019783; Score: 0.35
DE  Interaction: O95600; IntAct: EBI-29020196; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-29661630; Score: 0.27
DE  Interaction: P29322; IntAct: EBI-32718189; Score: 0.35
DE  Interaction: P08069; IntAct: EBI-32718669; Score: 0.35
DE  Interaction: Q06418; IntAct: EBI-32719716; Score: 0.35
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0042645;
GO  GO:0005635;
GO  GO:0045296;
GO  GO:0003723;
GO  GO:0046579;
GO  GO:0007165;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPAD
SQ  FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQ
SQ  RRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK
SQ  HTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ
//