ID  Q96EE3;
PN  Nucleoporin SEH1;
GN  SEH1L;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Lysosome membrane {ECO:0000269|PubMed:28199306}.
DR  UNIPROT: Q96EE3;
DR  UNIPROT: A8K5B1;
DR  UNIPROT: Q8NFU6;
DR  UNIPROT: Q96MH3;
DR  UNIPROT: Q9C069;
DR  PDB: 5A9Q;
DR  PDB: 7PEQ;
DR  Pfam: PF00400;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DR  OMIM: 609263;
DR  DisGeNET: 81929;
DE  Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.
DE  Reference Proteome: Yes;
DE  Interaction: A8CG34; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P02545; IntAct: EBI-16795756; Score: 0.27
DE  Interaction: P35658; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P46060; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P49790; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P49792; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P52948; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P55735; IntAct: EBI-11086798; Score: 0.62
DE  Interaction: P57740; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P63165; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P63279; IntAct: EBI-11105225; Score: 0.35
DE  Interaction: Q12769; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.35
DE  Interaction: Q53GS7; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q5SRE5; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-2563676; Score: 0.40
DE  Interaction: Q80U93; IntAct: EBI-11014856; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-2563157; Score: 0.40
DE  Interaction: Q8N1F7; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q8NFH3; IntAct: EBI-11086798; Score: 0.67
DE  Interaction: Q8NFH4; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q8NFH5; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q8TEM1; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q8WUM0; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q8WYP5; IntAct: EBI-9050503; Score: 0.49
DE  Interaction: Q92621; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: Q1EHW4; IntAct: EBI-922367; Score: 0.35
DE  Interaction: Q8IY92; IntAct: EBI-2371120; Score: 0.35
DE  Interaction: P24386; IntAct: EBI-2515120; Score: 0.40
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: Q14457; IntAct: EBI-3622591; Score: 0.35
DE  Interaction: Q93050; IntAct: EBI-3912272; Score: 0.37
DE  Interaction: P04578; IntAct: EBI-6176529; Score: 0.46
DE  Interaction: Q9BW27; IntAct: EBI-9032422; Score: 0.70
DE  Interaction: Q9H6Z9; IntAct: EBI-12503146; Score: 0.35
DE  Interaction: P19838; IntAct: EBI-11322417; Score: 0.35
DE  Interaction: E9QKK1; IntAct: EBI-10995761; Score: 0.35
DE  Interaction: Q99P88; IntAct: EBI-10997466; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: E9PUA5; IntAct: EBI-10999661; Score: 0.35
DE  Interaction: Q8VE37; IntAct: EBI-11043815; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: Q99PL5; IntAct: EBI-11066888; Score: 0.35
DE  Interaction: O75864; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P49368; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P50991; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: E9PF10; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q99567; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q6NUQ4; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q9BTX1; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P48643; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q6PJI9; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q9NRG9; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q96SK2; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q96S15; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q9NXC5; IntAct: EBI-11086798; Score: 0.53
DE  Interaction: O43683; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q99832; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q9UBU9; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P58043; IntAct: EBI-11102804; Score: 0.35
DE  Interaction: E5LBS6; IntAct: EBI-14062727; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q68D86; IntAct: EBI-21526180; Score: 0.35
DE  Interaction: P02511; IntAct: EBI-21564160; Score: 0.35
DE  Interaction: Q8IYS4; IntAct: EBI-21565697; Score: 0.35
DE  Interaction: Q99435; IntAct: EBI-21661256; Score: 0.35
DE  Interaction: Q9GZP0; IntAct: EBI-21663347; Score: 0.35
DE  Interaction: O15496; IntAct: EBI-21699277; Score: 0.35
DE  Interaction: Q86XD5; IntAct: EBI-21711466; Score: 0.35
DE  Interaction: Q96RS6; IntAct: EBI-20723623; Score: 0.35
DE  Interaction: Q5T011; IntAct: EBI-16752607; Score: 0.35
DE  Interaction: O95714; IntAct: EBI-16811721; Score: 0.35
DE  Interaction: Q83A11; IntAct: EBI-21286703; Score: 0.37
DE  Interaction: P10636; IntAct: EBI-20798291; Score: 0.35
DE  Interaction: O14929; IntAct: EBI-25478994; Score: 0.35
DE  Interaction: P0DTC2; IntAct: EBI-27088073; Score: 0.35
DE  Interaction: Q9NSY0; IntAct: EBI-28946547; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q93009; IntAct: EBI-30843837; Score: 0.44
DE  Interaction: Q9Y4G2; IntAct: EBI-32711159; Score: 0.35
GO  GO:0005829;
GO  GO:0061700;
GO  GO:0000776;
GO  GO:0005765;
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0031080;
GO  GO:0035859;
GO  GO:0005198;
GO  GO:0051315;
GO  GO:0051301;
GO  GO:0034198;
GO  GO:0050830;
GO  GO:0007080;
GO  GO:0051028;
GO  GO:1904262;
GO  GO:0006999;
GO  GO:0006913;
GO  GO:0032008;
GO  GO:1904263;
GO  GO:0015031;
GO  GO:0031503;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFD
SQ  RTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEIS
SQ  CKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
SQ  ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILK
SQ  GNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS
//