ID  Q96EF0;
PN  Myotubularin-related protein 8;
GN  MTMR8;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:16787938}.
DR  UNIPROT: Q96EF0;
DR  UNIPROT: Q5JT99;
DR  UNIPROT: Q9NXP6;
DR  PDB: 4Y7I;
DR  Pfam: PF06602;
DR  PROSITE: PS51339;
DR  PROSITE: PS00383;
DR  OMIM: 301061;
DR  DisGeNET: 55613;
DE  Function: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). {ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:26143924}.
DE  Reference Proteome: Yes;
DE  Interaction: Q6ZMQ8; IntAct: EBI-20980296; Score: 0.37
DE  Interaction: Q96QG7; IntAct: EBI-758404; Score: 0.81
DE  Interaction: P20839; IntAct: EBI-21610062; Score: 0.35
DE  Interaction: Q9Y216; IntAct: EBI-21836819; Score: 0.35
DE  Interaction: Q969Q4; IntAct: EBI-21883664; Score: 0.35
DE  Interaction: P21860; IntAct: EBI-20981036; Score: 0.37
DE  Interaction: Q9BUF5; IntAct: EBI-27113652; Score: 0.35
DE  Interaction: Q8WXG6; IntAct: EBI-27113652; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0032991;
GO  GO:0052629;
GO  GO:0106018;
GO  GO:0004438;
GO  GO:0010507;
GO  GO:0046856;
GO  GO:0016241;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVA
SQ  HFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICST
SQ  YPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVD
SQ  TRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAG
SQ  IFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFT
SQ  QFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTM
SQ  YGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQ
SQ  HLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDM
SQ  CTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ
//