ID  Q96PD7;
PN  Diacylglycerol O-acyltransferase 2;
GN  DGAT2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000269|PubMed:27184406}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
DR  UNIPROT: Q96PD7;
DR  UNIPROT: A6ND76;
DR  UNIPROT: Q5U810;
DR  UNIPROT: Q68CL3;
DR  UNIPROT: Q68DJ0;
DR  UNIPROT: Q8NDB7;
DR  UNIPROT: Q96BS0;
DR  UNIPROT: Q9BYE5;
DR  Pfam: PF03982;
DR  OMIM: 606983;
DR  DisGeNET: 84649;
DE  Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q9DCV3, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
DE  Reference Proteome: Yes;
DE  Interaction: P55072; IntAct: EBI-9519939; Score: 0.40
DE  Interaction: Q9UKV5; IntAct: EBI-9520083; Score: 0.40
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0030176;
GO  GO:0016021;
GO  GO:0043231;
GO  GO:0005811;
GO  GO:0005739;
GO  GO:1990578;
GO  GO:0048471;
GO  GO:0003846;
GO  GO:0004144;
GO  GO:0042803;
GO  GO:0050252;
GO  GO:0038183;
GO  GO:0071400;
GO  GO:0035356;
GO  GO:0042632;
GO  GO:0006651;
GO  GO:0046339;
GO  GO:0060613;
GO  GO:0055089;
GO  GO:0006071;
GO  GO:0006629;
GO  GO:0019915;
GO  GO:0035336;
GO  GO:0034383;
GO  GO:0006640;
GO  GO:0046322;
GO  GO:0045722;
GO  GO:0010867;
GO  GO:0090181;
GO  GO:0050746;
GO  GO:0097006;
GO  GO:0019432;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSF
SQ  LVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGY
SQ  HPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
SQ  AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLF
SQ  SSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
//