ID  Q96PP9;
PN  Guanylate-binding protein 4;
GN  GBP4;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:17266443}. Nucleus {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
DR  UNIPROT: Q96PP9;
DR  UNIPROT: B2R630;
DR  UNIPROT: Q05D63;
DR  UNIPROT: Q6NSL0;
DR  UNIPROT: Q86T99;
DR  Pfam: PF02263;
DR  Pfam: PF02841;
DR  PROSITE: PS51715;
DR  OMIM: 612466;
DR  DisGeNET: 115361;
DE  Function: Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P32456; IntAct: EBI-26472562; Score: 0.51
DE  Interaction: Q8TCS8; IntAct: EBI-20907752; Score: 0.40
DE  Interaction: P32455; IntAct: EBI-26472554; Score: 0.51
DE  Interaction: Q96PP9; IntAct: EBI-26472586; Score: 0.51
DE  Interaction: Q96PP8; IntAct: EBI-26472602; Score: 0.51
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0042802;
GO  GO:0042803;
GO  GO:0071346;
GO  GO:0050830;
GO  GO:0042832;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGF
SQ  PLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYV
SQ  TELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIR
SQ  HFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINS
SQ  GAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVD
SQ  TIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQ
SQ  SQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREH
SQ  ERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI
//