ID  Q96QA5;
PN  Gasdermin-A, C-terminal;
GN  GSDMA;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: [Gasdermin-A]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17471240}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}. [Gasdermin-A, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
DR  UNIPROT: Q96QA5;
DR  UNIPROT: Q32MC5;
DR  UNIPROT: Q86VE7;
DR  UNIPROT: Q8N1M6;
DR  Pfam: PF04598;
DR  Pfam: PF17708;
DR  OMIM: 611218;
DR  DisGeNET: 284110;
DE  Function: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. {ECO:0000269|PubMed:27281216}. [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216). Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216). Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216). The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216). {ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:27281216}.
DE  Reference Proteome: Yes;
DE  Interaction: O75593; IntAct: EBI-11320921; Score: 0.35
DE  Interaction: P02654; IntAct: EBI-23875424; Score: 0.56
DE  Interaction: P55056; IntAct: EBI-25158560; Score: 0.56
DE  Interaction: O43309; IntAct: EBI-21572679; Score: 0.35
DE  Interaction: Q9NU19; IntAct: EBI-21575852; Score: 0.35
DE  Interaction: Q9UMR2; IntAct: EBI-21616596; Score: 0.35
DE  Interaction: Q15915; IntAct: EBI-21696712; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q9P2S5; IntAct: EBI-25486895; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568044; Score: 0.35
DE  Interaction: O43781; IntAct: EBI-28931148; Score: 0.35
DE  Interaction: Q14296; IntAct: EBI-28941126; Score: 0.35
GO  GO:0005829;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005546;
GO  GO:0070273;
GO  GO:0001786;
GO  GO:0006915;
GO  GO:0042742;
GO  GO:0070269;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q5Y4Y6};
SQ  MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFG
SQ  FKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETV
SQ  QEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEE
SQ  KVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPK
SQ  DVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLT
SQ  EALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS
//