ID  Q96RT1;
PN  Erbin;
GN  ERBIN;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell junction, hemidesmosome {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:11375975}. Nucleus membrane {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
DR  UNIPROT: Q96RT1;
DR  UNIPROT: A0AVR1;
DR  UNIPROT: B4E3F1;
DR  UNIPROT: B7ZLV9;
DR  UNIPROT: E7EQW9;
DR  UNIPROT: E9PCR8;
DR  UNIPROT: Q1RMD0;
DR  UNIPROT: Q86W38;
DR  UNIPROT: Q9NR18;
DR  UNIPROT: Q9NW48;
DR  UNIPROT: Q9ULJ5;
DR  PDB: 1MFG;
DR  PDB: 1MFL;
DR  PDB: 1N7T;
DR  PDB: 2H3L;
DR  PDB: 2QBW;
DR  PDB: 3CH8;
DR  PDB: 6Q0M;
DR  PDB: 6Q0N;
DR  PDB: 6Q0U;
DR  PDB: 6UBH;
DR  PDB: 7LUL;
DR  Pfam: PF13855;
DR  Pfam: PF00595;
DR  PROSITE: PS51450;
DR  PROSITE: PS50106;
DR  OMIM: 606944;
DR  DisGeNET: 55914;
DE  Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
DE  Reference Proteome: Yes;
DE  Interaction: O43542; IntAct: EBI-11129266; Score: 0.35
DE  Interaction: P00533; IntAct: EBI-32720286; Score: 0.27
DE  Interaction: Q16620; IntAct: EBI-32724423; Score: 0.27
DE  Interaction: Q5XI72; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q6AXS5; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: O95405; IntAct: EBI-7255424; Score: 0.37
DE  Interaction: Q99569; IntAct: EBI-8449263; Score: 0.63
DE  Interaction: P35222; IntAct: EBI-8449492; Score: 0.27
DE  Interaction: Q9UQ13; IntAct: EBI-993893; Score: 0.62
DE  Interaction: Q15796; IntAct: EBI-2695978; Score: 0.40
DE  Interaction: P84022; IntAct: EBI-2696171; Score: 0.40
DE  Interaction: Q5NID9; IntAct: EBI-2805400; Score: 0.00
DE  Interaction: Q8CZZ5; IntAct: EBI-2841600; Score: 0.00
DE  Interaction: Q8CZQ2; IntAct: EBI-2865700; Score: 0.00
DE  Interaction: P25054; IntAct: EBI-3436880; Score: 0.00
DE  Interaction: P01106; IntAct: EBI-3893063; Score: 0.35
DE  Interaction: P25791; IntAct: EBI-3939532; Score: 0.37
DE  Interaction: P40763; IntAct: EBI-3940529; Score: 0.37
DE  Interaction: B1AYL1; IntAct: EBI-8068438; Score: 0.44
DE  Interaction: P36873; IntAct: EBI-6911905; Score: 0.57
DE  Interaction: P57078; IntAct: EBI-12503575; Score: 0.35
DE  Interaction: A2AUM9; IntAct: EBI-10994361; Score: 0.35
DE  Interaction: Q96H55; IntAct: EBI-11031416; Score: 0.35
DE  Interaction: Q8C767; IntAct: EBI-11064501; Score: 0.35
DE  Interaction: Q5HZK1; IntAct: EBI-11074242; Score: 0.35
DE  Interaction: G3X972; IntAct: EBI-11079358; Score: 0.35
DE  Interaction: Q16643; IntAct: EBI-11080402; Score: 0.35
DE  Interaction: Q9NYZ3; IntAct: EBI-11081743; Score: 0.35
DE  Interaction: Q00610; IntAct: EBI-11082478; Score: 0.35
DE  Interaction: Q8BGH2; IntAct: EBI-11097023; Score: 0.35
DE  Interaction: P53667; IntAct: EBI-11101207; Score: 0.35
DE  Interaction: P09803; IntAct: EBI-11106849; Score: 0.35
DE  Interaction: Q86X19; IntAct: EBI-11390509; Score: 0.27
DE  Interaction: Q9HC29; IntAct: EBI-11420226; Score: 0.66
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: P03496; IntAct: EBI-11519918; Score: 0.37
DE  Interaction: Q2PJP0; IntAct: EBI-11520503; Score: 0.37
DE  Interaction: Q6DP93; IntAct: EBI-11520678; Score: 0.37
DE  Interaction: P03508; IntAct: EBI-11520965; Score: 0.37
DE  Interaction: Q20MH4; IntAct: EBI-11521170; Score: 0.37
DE  Interaction: Q9UQB3; IntAct: EBI-11793333; Score: 0.40
DE  Interaction: O00192; IntAct: EBI-11793379; Score: 0.40
DE  Interaction: Q9BY21; IntAct: EBI-11793409; Score: 0.40
DE  Interaction: Q96DL1; IntAct: EBI-11793419; Score: 0.40
DE  Interaction: Q8NHY3; IntAct: EBI-11793429; Score: 0.40
DE  Interaction: A3EX99; IntAct: EBI-11794147; Score: 0.40
DE  Interaction: A3EXD5; IntAct: EBI-11794185; Score: 0.40
DE  Interaction: P06427; IntAct: EBI-11794195; Score: 0.40
DE  Interaction: Q9IDV3; IntAct: EBI-11794220; Score: 0.40
DE  Interaction: Q1A244; IntAct: EBI-11794243; Score: 0.40
DE  Interaction: P03126; IntAct: EBI-11794253; Score: 0.40
DE  Interaction: P50804; IntAct: EBI-11794263; Score: 0.40
DE  Interaction: P0C9G5; IntAct: EBI-11794280; Score: 0.40
DE  Interaction: A3EXD4; IntAct: EBI-11794297; Score: 0.40
DE  Interaction: P89432; IntAct: EBI-11794318; Score: 0.40
DE  Interaction: P0C213; IntAct: EBI-11794328; Score: 0.40
DE  Interaction: Q18LE1; IntAct: EBI-11794586; Score: 0.40
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: P62136; IntAct: EBI-14025896; Score: 0.42
DE  Interaction: Q96H86; IntAct: EBI-21521634; Score: 0.35
DE  Interaction: Q7Z398; IntAct: EBI-21528160; Score: 0.35
DE  Interaction: A8K8V0; IntAct: EBI-21612043; Score: 0.35
DE  Interaction: P09017; IntAct: EBI-21634836; Score: 0.35
DE  Interaction: Q8IZ69; IntAct: EBI-21636338; Score: 0.35
DE  Interaction: Q8WV44; IntAct: EBI-21636495; Score: 0.35
DE  Interaction: Q96IQ9; IntAct: EBI-21636586; Score: 0.35
DE  Interaction: Q9H9D4; IntAct: EBI-21642543; Score: 0.35
DE  Interaction: O43296; IntAct: EBI-21725229; Score: 0.35
DE  Interaction: Q49MI3; IntAct: EBI-21731388; Score: 0.35
DE  Interaction: P43235; IntAct: EBI-21781359; Score: 0.35
DE  Interaction: Q8TA94; IntAct: EBI-21783979; Score: 0.35
DE  Interaction: Q9NY56; IntAct: EBI-21795463; Score: 0.35
DE  Interaction: Q6ZMY9; IntAct: EBI-21818150; Score: 0.35
DE  Interaction: P20160; IntAct: EBI-21867396; Score: 0.35
DE  Interaction: Q14CB8; IntAct: EBI-21871748; Score: 0.35
DE  Interaction: Q9P0T4; IntAct: EBI-21882203; Score: 0.35
DE  Interaction: P15311; IntAct: EBI-16791848; Score: 0.27
DE  Interaction: P49841; IntAct: EBI-16793176; Score: 0.27
DE  Interaction: P11279; IntAct: EBI-16795491; Score: 0.27
DE  Interaction: Q9NPJ6; IntAct: EBI-25472202; Score: 0.27
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: Q2LC84; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q04970; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P60868; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: A0A0G2K8Z9; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: G3V7V7; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D4A9L2; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: A0A0G2K654; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q27W01; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: B2RYP6; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: G3V6S1; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P62890; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P35427; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q8K1Q0; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: B5DFM8; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q6AYK8; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q4V8C8; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q920F5; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D4A3K5; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: E9PT65; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P62850; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: G3V9L1; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: M0R6J0; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P62278; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q6IMY8; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q62780; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P24368; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: A0A0G2K719; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q7TT49; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P09875; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P09895; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P62893; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q9R0T3; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: A0A0G2JW88; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: M0R9L3; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q5RK00; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: E9PU01; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q3KRF2; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: F1M124; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D3ZZT9; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q9JJ31; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q63186; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P17078; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P13471; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: F1MAF2; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q6AYE2; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D4AD15; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P50904; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: B2GV09; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P05197; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: G3V9N7; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q9Z1W6; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P62961; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: A0A096MK30; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D4A4R1; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P30009; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q5M7V8; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P47198; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P31000; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P61314; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: D3Z898; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q5U2Q7; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q5XIM5; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P13086; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: Q5M963; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P81795; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: M0R9T2; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P41743; IntAct: EBI-25380638; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: K9N5R3; IntAct: EBI-26973414; Score: 0.40
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: A0A0H3NFP4; IntAct: EBI-27055788; Score: 0.27
DE  Interaction: P13569; IntAct: EBI-27087549; Score: 0.35
DE  Interaction: Q99592; IntAct: EBI-27093179; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952324; Score: 0.27
DE  Interaction: Q13886; IntAct: EBI-29000705; Score: 0.35
DE  Interaction: P30530; IntAct: EBI-32717503; Score: 0.35
DE  Interaction: P29317; IntAct: EBI-32720711; Score: 0.27
DE  Interaction: P29320; IntAct: EBI-32720767; Score: 0.27
DE  Interaction: P54764; IntAct: EBI-32720816; Score: 0.27
DE  Interaction: P54756; IntAct: EBI-32720907; Score: 0.27
DE  Interaction: Q15375; IntAct: EBI-32721052; Score: 0.27
DE  Interaction: P21802; IntAct: EBI-32721907; Score: 0.27
DE  Interaction: P22455; IntAct: EBI-32722168; Score: 0.27
DE  Interaction: Q06124; IntAct: EBI-32723738; Score: 0.27
DE  Interaction: Q16288; IntAct: EBI-32724526; Score: 0.27
DE  Interaction: P16234; IntAct: EBI-32724889; Score: 0.27
DE  Interaction: Q01973; IntAct: EBI-32725295; Score: 0.27
DE  Interaction: Q6J9G0; IntAct: EBI-32731895; Score: 0.27
DE  Interaction: P12830; IntAct: EBI-34580821; Score: 0.35
GO  GO:0009925;
GO  GO:0005604;
GO  GO:0016323;
GO  GO:0030054;
GO  GO:0005737;
GO  GO:0098978;
GO  GO:0030056;
GO  GO:0031965;
GO  GO:0016607;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0098794;
GO  GO:0005176;
GO  GO:0005102;
GO  GO:0005200;
GO  GO:0045175;
GO  GO:0007155;
GO  GO:0071356;
GO  GO:0007173;
GO  GO:0045197;
GO  GO:0007229;
GO  GO:0045104;
GO  GO:0071638;
GO  GO:0032088;
GO  GO:0070433;
GO  GO:0046579;
GO  GO:0006605;
GO  GO:0099072;
GO  GO:0032496;
GO  GO:0032495;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND
SQ  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL
SQ  TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
SQ  NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQ
SQ  LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSD
SQ  NQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
SQ  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQK
SQ  ISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKET
SQ  DSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
SQ  KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINS
SQ  KEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGG
SQ  LKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
SQ  PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANT
SQ  AYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMM
SQ  PGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
SQ  LRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQAS
SQ  VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQ
SQ  PEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
//