ID  Q96S99;
PN  Pleckstrin homology domain-containing family F member 1;
GN  PLEKHF1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
DR  UNIPROT: Q96S99;
DR  UNIPROT: Q96K11;
DR  UNIPROT: Q9BUB9;
DR  Pfam: PF01363;
DR  Pfam: PF00169;
DR  PROSITE: PS50003;
DR  PROSITE: PS50178;
DR  OMIM: 615200;
DR  DisGeNET: 79156;
DE  Function: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
DE  Reference Proteome: Yes;
DE  Interaction: P13805; IntAct: EBI-754699; Score: 0.37
DE  Interaction: Q96EK5; IntAct: EBI-757246; Score: 0.37
DE  Interaction: Q96JM7; IntAct: EBI-10293337; Score: 0.56
DE  Interaction: O95810; IntAct: EBI-24333775; Score: 0.56
DE  Interaction: Q9UKJ5; IntAct: EBI-24626977; Score: 0.56
DE  Interaction: Q86SE8; IntAct: EBI-24411098; Score: 0.56
DE  Interaction: O95379; IntAct: EBI-24584209; Score: 0.56
GO  GO:0005769;
GO  GO:0010008;
GO  GO:0005765;
GO  GO:0005764;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0046872;
GO  GO:0035091;
GO  GO:0032266;
GO  GO:0070273;
GO  GO:0010314;
GO  GO:0006915;
GO  GO:0007032;
GO  GO:0008333;
GO  GO:0010508;
GO  GO:2001244;
GO  GO:0072659;
GO  GO:0016050;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVDHLANTEINSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHII
SQ  PLEEVTLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICMR
SQ  CTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEEAEEQGAGSPGQPAHLARPICG
SQ  ASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
//