ID  Q96T37;
PN  RNA-binding protein 15;
GN  RBM15;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus speckle {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:24100041}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Nucleus membrane {ECO:0000269|PubMed:19786495}; Peripheral membrane protein {ECO:0000269|PubMed:19786495}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000269|PubMed:19786495}.
DR  UNIPROT: Q96T37;
DR  UNIPROT: A1A693;
DR  UNIPROT: Q3ZB86;
DR  UNIPROT: Q4V760;
DR  UNIPROT: Q5D058;
DR  UNIPROT: Q5T613;
DR  UNIPROT: Q86VW9;
DR  UNIPROT: Q96PE4;
DR  UNIPROT: Q96SC5;
DR  UNIPROT: Q96SC6;
DR  UNIPROT: Q96SC9;
DR  UNIPROT: Q96SD0;
DR  UNIPROT: Q96T38;
DR  UNIPROT: Q9BRA5;
DR  UNIPROT: Q9H6R8;
DR  UNIPROT: Q9H9Y0;
DR  Pfam: PF00076;
DR  Pfam: PF07744;
DR  PROSITE: PS50102;
DR  PROSITE: PS50917;
DR  OMIM: 606077;
DR  DisGeNET: 64783;
DE  Function: RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
DE  Disease: Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. {ECO:0000269|PubMed:11344311, ECO:0000269|PubMed:11431691}.
DE  Reference Proteome: Yes;
DE  Interaction: Q13137; IntAct: EBI-10293900; Score: 0.56
DE  Interaction: Q8NDT2; IntAct: EBI-21889356; Score: 0.35
DE  Interaction: Q8NFQ8; IntAct: EBI-21508086; Score: 0.35
DE  Interaction: O60346; IntAct: EBI-2514920; Score: 0.54
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q9H492; IntAct: EBI-3044058; Score: 0.35
DE  Interaction: P45983; IntAct: EBI-7235213; Score: 0.37
DE  Interaction: P78362; IntAct: EBI-6658735; Score: 0.44
DE  Interaction: Q7TSJ6; IntAct: EBI-8798662; Score: 0.27
DE  Interaction: Q8IVL1; IntAct: EBI-10293910; Score: 0.56
DE  Interaction: Q92841; IntAct: EBI-10293920; Score: 0.56
DE  Interaction: Q9BRK4; IntAct: EBI-10293942; Score: 0.56
DE  Interaction: Q9C0F1; IntAct: EBI-10293956; Score: 0.56
DE  Interaction: Q96L14; IntAct: EBI-11022408; Score: 0.35
DE  Interaction: O60825; IntAct: EBI-11070701; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-11105437; Score: 0.35
DE  Interaction: Q6PDM2; IntAct: EBI-11155641; Score: 0.35
DE  Interaction: Q68CZ1; IntAct: EBI-11368346; Score: 0.27
DE  Interaction: Q8N0Z3; IntAct: EBI-11392023; Score: 0.27
DE  Interaction: Q9UJV9; IntAct: EBI-11473486; Score: 0.35
DE  Interaction: Q9H2G4; IntAct: EBI-24501963; Score: 0.56
DE  Interaction: Q8IZP0; IntAct: EBI-24422299; Score: 0.56
DE  Interaction: I6T1Z2; IntAct: EBI-12581451; Score: 0.35
DE  Interaction: Q9NZQ3; IntAct: EBI-21676174; Score: 0.35
DE  Interaction: Q8N307; IntAct: EBI-21729950; Score: 0.35
DE  Interaction: Q86VM9; IntAct: EBI-21769401; Score: 0.35
DE  Interaction: P40967; IntAct: EBI-21773380; Score: 0.35
DE  Interaction: Q86U44; IntAct: EBI-20594935; Score: 0.35
DE  Interaction: Q15007; IntAct: EBI-20595349; Score: 0.35
DE  Interaction: Q12824; IntAct: EBI-20624550; Score: 0.27
DE  Interaction: Q09666; IntAct: EBI-20913094; Score: 0.40
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q9ULK4; IntAct: EBI-25472850; Score: 0.35
DE  Interaction: Q09161; IntAct: EBI-26396507; Score: 0.35
DE  Interaction: Q53F19; IntAct: EBI-26396827; Score: 0.35
DE  Interaction: P48431; IntAct: EBI-26574478; Score: 0.35
DE  Interaction: P07947; IntAct: EBI-30849745; Score: 0.44
DE  Interaction: P30530; IntAct: EBI-32719959; Score: 0.27
DE  Interaction: P22607; IntAct: EBI-32721979; Score: 0.27
DE  Interaction: P35968; IntAct: EBI-32723270; Score: 0.27
DE  Interaction: Q12866; IntAct: EBI-32723870; Score: 0.27
GO  GO:0031965;
GO  GO:0016607;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0036396;
GO  GO:0003729;
GO  GO:0003723;
GO  GO:0001569;
GO  GO:0009048;
GO  GO:0045638;
GO  GO:0060674;
GO  GO:0007221;
GO  GO:0000381;
GO  GO:0045652;
GO  GO:0001510;
GO  GO:0048536;
GO  GO:0038163;
GO  GO:0060412;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:19786495};
SQ  MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRGGEDSTSRGERSKKLGGSGGS
SQ  NGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSA
SQ  PGGGDGAEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVL
SQ  YDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPP
SQ  PPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVI
SQ  TEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGT
SQ  IRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDAFGHRAPDP
SQ  LRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTAATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPR
SQ  KRRLPEESGGRHLDRSPESDRPRKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRK
SQ  NSASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASASPKLCLAWQGMLLLKNSNFP
SQ  SNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDT
SQ  ATSTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQI
SQ  GVRYENKKRENLALTLL
//