ID  Q99KD5;
PN  Protein unc-45 homolog A;
GN  Unc45a;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominant in the perinuclear region. Little protein in the nucleus (By similarity). {ECO:0000250}.
DR  UNIPROT: Q99KD5;
DR  UNIPROT: Q3TKV6;
DR  UNIPROT: Q8BFT3;
DR  UNIPROT: Q8C157;
DR  Pfam: PF13181;
DR  Pfam: PF11701;
DR  PROSITE: PS50005;
DR  PROSITE: PS50293;
DE  Function: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen. {ECO:0000250, ECO:0000269|PubMed:12356907, ECO:0000269|PubMed:9209433, ECO:0000305}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0016607;
GO  GO:0048471;
GO  GO:0051879;
GO  GO:0030154;
GO  GO:0061077;
GO  GO:0007517;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTVSGPETPEPRPSDPGASSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESE
SQ  ASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQIL
SQ  LDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTEETDLMLAALRTLVGICSEHQSRTVATLSVLGTR
SQ  RVVSILGVENQAVSLAACHLLQVIFDALKEGVKKGFRGKEGAIIVDPARELKVLINSLLELLTEVGVSGQGRDNALTLLI
SQ  KMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSLQDAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIR
SQ  NWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEREEEQLVAVEALIHAAGKAKRASFITANGVS
SQ  LLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADV
SQ  KEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLL
SQ  AAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSN
SQ  PEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMC
SQ  NLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPALCSRIPQVTTHWLEILQALLLSPNQELQH
SQ  RGTVVVLNMMQSSKEIAGTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE
//