ID  Q99LI2;
PN  Chloride channel CLIC-like protein 1;
GN  Clcc1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WU61}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WU61}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9WU61}; Multi-pass membrane protein {ECO:0000255}. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. {ECO:0000250|UniProtKB:Q96S66}.
DR  UNIPROT: Q99LI2;
DR  UNIPROT: A2AEK9;
DR  Pfam: PF05934;
DE  Function: Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (PubMed:30157172). {ECO:0000250|UniProtKB:Q9WU61, ECO:0000269|PubMed:30157172}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9CZE3; IntAct: EBI-11570876; Score: 0.35
DE  Interaction: Q9D0P8; IntAct: EBI-11571153; Score: 0.35
DE  Interaction: Q8BIZ1; IntAct: EBI-26595802; Score: 0.35
GO  GO:0034707;
GO  GO:0005737;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0043231;
GO  GO:0044233;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005254;
GO  GO:0006821;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLCRLLLCECLLLITGYAHDDDWIDPTDMLNYDAASGTMRKSQVRSGTSEKKEVSPDSSEAEELSDCLHRLDSLTHKVDS
SQ  CEKKKMKDYESQSNPVFRRYLNKILIEAGKLGLPDENKVEMRYDAEILLSRQTLLEIQKFLSGEEWKPGALDDALSDILI
SQ  NFKCHDSEAWKWQFEDYFGVDPYNVFMVLLCLLCLVVLVATELWTYVRWYTQMKRIFIISFLLSLAWNWIYLYKMAFAQH
SQ  QANIAGMEPFDNLCAKKMDWTGSLWEWFTSSWTYKDDPCQKYYELLIVNPIWLVPPTKALAITFTNFVTEPLKHIGKGAG
SQ  EFIKALMKEIPVLLQIPVLAILALAVLSFCYGAGRSVPMLRHFGGPDREPPRALEPDDRRRQKGLDYRLHGGAGDADFSY
SQ  RGPAGSIEQGPYDKMHASKRDALRQRFHSGNKSPEVLRAFDLPDTEAQEHPEVVPSHKSPIMNTNLETGELPGESTPTEY
SQ  SQSAKDVSGQVPSAGKSSPTVDKAQLKTDSECSPPGGCPPSKEAAVAAHGTEPVSSPCG
//