ID  Q99M66;
PN  Bcl-2-like protein 10;
GN  Bcl2l10;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Mitochondrion {ECO:0000250|UniProtKB:Q9HD36}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HD36}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9HD36}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria- associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). {ECO:0000250|UniProtKB:Q9HD36}.
DR  UNIPROT: Q99M66;
DR  Pfam: PF00452;
DR  PROSITE: PS50062;
DR  PROSITE: PS01258;
DE  Function: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). {ECO:0000250|UniProtKB:Q9HD36, ECO:0000250|UniProtKB:Q9Z0F3}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0044233;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0031965;
GO  GO:0005819;
GO  GO:0005509;
GO  GO:0089720;
GO  GO:0042802;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0006915;
GO  GO:0097192;
GO  GO:0097193;
GO  GO:0008630;
GO  GO:0031023;
GO  GO:0043066;
GO  GO:2001240;
GO  GO:2001243;
GO  GO:0048709;
GO  GO:0043065;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGDPLQDRTRRLLTDYILFCARAPNTPEPLPTSVEAALLRSVTSQIQQEHQDLFNSFRDYQGNRLELVTQMADELLSNDQ
SQ  EFNWGRLVMLLAFVGTLMNQDRTVKRRRDQRNRLLLERDCYLIVSLLYNRLTGRHRSWLEAHGGWDGFCQFFKNPLPPGF
SQ  WRRLLIRAILSCFFATAIFYIWKCL
//