ID  Q99N46;
PN  Brain protein I3;
GN  I3;
OS  10141;
SL  Nucleus Position: SL-0198;
SL  Comments: Lysosome membrane {ECO:0000250|UniProtKB:O95415}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
DR  UNIPROT: Q99N46;
DR  Pfam: PF10164;
DE  Function: Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver. {ECO:0000250|UniProtKB:O95415}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0005765;
GO  GO:0048471;
GO  GO:0042802;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDHKPLLQERPPAYNLEAGQGDYACGAPGYGAIPSAPPPPPYPYLVTGIPTPHPRVYSIHSRTVTRYPANSIVVVGGCPV
SQ  CRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNCGATFT
//