ID  Q99N69;
PN  Leupaxin;
GN  Lpxn;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {ECO:0000250}.
DR  UNIPROT: Q99N69;
DR  Pfam: PF00412;
DR  PROSITE: PS00478;
DR  PROSITE: PS50023;
DE  Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:19917054}.
DE  Reference Proteome: Yes;
DE  Interaction: Q62406; IntAct: EBI-658892; Score: 0.37
DE  Interaction: A0A0F6AW51; IntAct: EBI-13950465; Score: 0.40
GO  GO:0042995;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005925;
GO  GO:0016607;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0002102;
GO  GO:0046872;
GO  GO:0003712;
GO  GO:0043542;
GO  GO:0050859;
GO  GO:0007162;
GO  GO:0033628;
GO  GO:0034446;
GO  GO:0007179;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEELDALLEELERCTFQDSEEYSNPVSCHLDQQSTEESKIPQTPKTLSSQGNTSPLKVQLVYATNIQEPNVYSEVQEPKE
SQ  SVLPPKTSAAAQLDELMAHLSEMQAKVSVKADTSRKPLPDQQDHKASLDSMLGDLEQELQDLGIATVPKGYCASCQKPIA
SQ  GKVIHALGQSWHPEHFVCTHCKEELGSSPFFERSGLAYCSKDYHRLFSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHC
SQ  GEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELDGRPFCELH
SQ  YHHRRGTLCHDCGQPITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCEKCFTKLFSQ
//