ID  Q9BVL2;
PN  Nucleoporin p58/p45;
GN  NUP58;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P70581}. Nucleus membrane {ECO:0000250|UniProtKB:P70581}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70581}; Cytoplasmic side {ECO:0000250|UniProtKB:P70581}. Nucleus membrane {ECO:0000250|UniProtKB:P70581}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70581}; Nucleoplasmic side {ECO:0000250|UniProtKB:P70581}. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. {ECO:0000250|UniProtKB:P70581}.
DR  UNIPROT: Q9BVL2;
DR  UNIPROT: A6NI12;
DR  UNIPROT: B4DZJ1;
DR  UNIPROT: O43160;
DR  UNIPROT: Q5JRG2;
DR  UNIPROT: Q5JRG5;
DR  PDB: 4JO7;
DR  PDB: 4JO9;
DR  PDB: 4JQ5;
DR  PDB: 5IJN;
DR  PDB: 5IJO;
DR  PDB: 7PER;
DR  OMIM: 607615;
DR  DisGeNET: 9818;
DE  Function: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}.
DE  Reference Proteome: Yes;
DE  Interaction: A1KXE4; IntAct: EBI-25908575; Score: 0.56
DE  Interaction: O14770; IntAct: EBI-24450131; Score: 0.56
DE  Interaction: O15504; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-25491191; Score: 0.53
DE  Interaction: P20749; IntAct: EBI-25907809; Score: 0.56
DE  Interaction: P35658; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: P37198; IntAct: EBI-8635195; Score: 0.80
DE  Interaction: P49792; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: P52948; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: P57740; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q5SRE5; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q7Z3B4; IntAct: EBI-10299822; Score: 0.92
DE  Interaction: Q8N1F7; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q8NFH5; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q8WUX9; IntAct: EBI-25908519; Score: 0.56
DE  Interaction: Q92621; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q99598; IntAct: EBI-25907995; Score: 0.56
DE  Interaction: Q9BTX1; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: A0A6L8PKS7; IntAct: EBI-2811590; Score: 0.00
DE  Interaction: P25054; IntAct: EBI-3437349; Score: 0.00
DE  Interaction: Q9P2A4; IntAct: EBI-8635212; Score: 0.78
DE  Interaction: P27361; IntAct: EBI-7201994; Score: 0.37
DE  Interaction: P42858; IntAct: EBI-6451221; Score: 0.74
DE  Interaction: Q13077; IntAct: EBI-10299812; Score: 0.84
DE  Interaction: Q9UMX0; IntAct: EBI-10299842; Score: 0.56
DE  Interaction: Q99988; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q969P6; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q9BSD7; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: P11532; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: O15440; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q96A73; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q96BD5; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q14746; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q9BPU9; IntAct: EBI-11377507; Score: 0.27
DE  Interaction: Q96NL6; IntAct: EBI-11396361; Score: 0.27
DE  Interaction: Q96JB2; IntAct: EBI-24514268; Score: 0.72
DE  Interaction: Q7Z3Y7; IntAct: EBI-24531449; Score: 0.56
DE  Interaction: Q9NYP9; IntAct: EBI-24615263; Score: 0.72
DE  Interaction: O95994; IntAct: EBI-24618865; Score: 0.56
DE  Interaction: Q96KN3; IntAct: EBI-24406190; Score: 0.56
DE  Interaction: Q9Y2V7; IntAct: EBI-24474216; Score: 0.56
DE  Interaction: Q7Z3Y8; IntAct: EBI-24474479; Score: 0.56
DE  Interaction: Q9UHD9; IntAct: EBI-24475280; Score: 0.56
DE  Interaction: Q14525; IntAct: EBI-24599138; Score: 0.72
DE  Interaction: P55347; IntAct: EBI-24638583; Score: 0.72
DE  Interaction: Q96P53; IntAct: EBI-21607501; Score: 0.35
DE  Interaction: Q96A37; IntAct: EBI-21627270; Score: 0.35
DE  Interaction: Q5VX52; IntAct: EBI-21635815; Score: 0.35
DE  Interaction: Q9NVF7; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q9HD26; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q9BZF3; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q96AX9; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q15075; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: O75150; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q9H1M0; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: Q96FN4; IntAct: EBI-21659658; Score: 0.35
DE  Interaction: O75830; IntAct: EBI-20916376; Score: 0.40
DE  Interaction: Q9BYV2; IntAct: EBI-22024904; Score: 0.00
DE  Interaction: Q6P1K2; IntAct: EBI-25907819; Score: 0.56
DE  Interaction: O75886; IntAct: EBI-25908093; Score: 0.56
DE  Interaction: Q99996; IntAct: EBI-25908085; Score: 0.56
DE  Interaction: O60636; IntAct: EBI-25908077; Score: 0.56
DE  Interaction: Q14154; IntAct: EBI-25908069; Score: 0.56
DE  Interaction: Q6ZU52; IntAct: EBI-25908059; Score: 0.56
DE  Interaction: A1A512; IntAct: EBI-25908051; Score: 0.56
DE  Interaction: Q13503; IntAct: EBI-25908043; Score: 0.56
DE  Interaction: Q52LW3; IntAct: EBI-25908035; Score: 0.56
DE  Interaction: O00303; IntAct: EBI-25908027; Score: 0.56
DE  Interaction: Q92783; IntAct: EBI-25908019; Score: 0.56
DE  Interaction: Q8WUW1; IntAct: EBI-25908011; Score: 0.56
DE  Interaction: P49459; IntAct: EBI-25908003; Score: 0.56
DE  Interaction: Q86WV8; IntAct: EBI-25907987; Score: 0.56
DE  Interaction: Q14765; IntAct: EBI-25907979; Score: 0.56
DE  Interaction: Q96GM5; IntAct: EBI-25907971; Score: 0.56
DE  Interaction: P47804; IntAct: EBI-25907963; Score: 0.56
DE  Interaction: P35998; IntAct: EBI-25907955; Score: 0.56
DE  Interaction: Q9BR81; IntAct: EBI-25907939; Score: 0.56
DE  Interaction: Q13562; IntAct: EBI-25907931; Score: 0.56
DE  Interaction: P02795; IntAct: EBI-25907923; Score: 0.56
DE  Interaction: P27338; IntAct: EBI-25907915; Score: 0.56
DE  Interaction: P80217; IntAct: EBI-25907899; Score: 0.56
DE  Interaction: Q06547; IntAct: EBI-25907891; Score: 0.56
DE  Interaction: O15287; IntAct: EBI-25907875; Score: 0.56
DE  Interaction: P41970; IntAct: EBI-25907867; Score: 0.56
DE  Interaction: H3BUJ7; IntAct: EBI-25907859; Score: 0.56
DE  Interaction: Q14117; IntAct: EBI-25907851; Score: 0.56
DE  Interaction: P24310; IntAct: EBI-25907843; Score: 0.56
DE  Interaction: Q86WV5; IntAct: EBI-25907835; Score: 0.56
DE  Interaction: Q13887; IntAct: EBI-25907827; Score: 0.56
DE  Interaction: Q9NP70; IntAct: EBI-25907801; Score: 0.56
DE  Interaction: Q9BQS8; IntAct: EBI-25908407; Score: 0.56
DE  Interaction: O75934; IntAct: EBI-25908101; Score: 0.56
DE  Interaction: Q9BV99; IntAct: EBI-25908389; Score: 0.56
DE  Interaction: Q9BRX5; IntAct: EBI-25908381; Score: 0.56
DE  Interaction: Q969X5; IntAct: EBI-25908373; Score: 0.56
DE  Interaction: Q6GQQ9; IntAct: EBI-25908363; Score: 0.56
DE  Interaction: Q9NS71; IntAct: EBI-25908355; Score: 0.56
DE  Interaction: Q9BXU0; IntAct: EBI-25908347; Score: 0.56
DE  Interaction: Q96FT7; IntAct: EBI-25908331; Score: 0.56
DE  Interaction: Q96EP0; IntAct: EBI-25908313; Score: 0.56
DE  Interaction: Q96EN9; IntAct: EBI-25908305; Score: 0.56
DE  Interaction: Q6NXG1; IntAct: EBI-25908297; Score: 0.56
DE  Interaction: Q9ULW8; IntAct: EBI-25908271; Score: 0.56
DE  Interaction: Q8IXH7; IntAct: EBI-25908263; Score: 0.56
DE  Interaction: P57682; IntAct: EBI-25908255; Score: 0.56
DE  Interaction: Q9BPZ3; IntAct: EBI-25908247; Score: 0.56
DE  Interaction: P57054; IntAct: EBI-25908237; Score: 0.56
DE  Interaction: Q9BT78; IntAct: EBI-25908229; Score: 0.56
DE  Interaction: Q9H347; IntAct: EBI-25908221; Score: 0.56
DE  Interaction: Q9BY12; IntAct: EBI-25908211; Score: 0.56
DE  Interaction: Q9NNX6; IntAct: EBI-25908203; Score: 0.56
DE  Interaction: Q8N490; IntAct: EBI-25908187; Score: 0.56
DE  Interaction: Q6PID6; IntAct: EBI-25908179; Score: 0.56
DE  Interaction: Q13352; IntAct: EBI-25908169; Score: 0.56
DE  Interaction: Q8TBE0; IntAct: EBI-25908153; Score: 0.56
DE  Interaction: O43482; IntAct: EBI-25908145; Score: 0.56
DE  Interaction: O75935; IntAct: EBI-25908137; Score: 0.56
DE  Interaction: Q99871; IntAct: EBI-25908127; Score: 0.56
DE  Interaction: O95229; IntAct: EBI-25908119; Score: 0.56
DE  Interaction: O75528; IntAct: EBI-25908109; Score: 0.56
DE  Interaction: Q0VDD7; IntAct: EBI-25908397; Score: 0.56
DE  Interaction: Q86TI2; IntAct: EBI-25908509; Score: 0.56
DE  Interaction: Q8IY31; IntAct: EBI-25908493; Score: 0.56
DE  Interaction: Q8NE08; IntAct: EBI-25908475; Score: 0.56
DE  Interaction: Q86U90; IntAct: EBI-25908417; Score: 0.56
DE  Interaction: Q9BV20; IntAct: EBI-25908459; Score: 0.56
DE  Interaction: Q8IUR5; IntAct: EBI-25908451; Score: 0.56
DE  Interaction: Q9H410; IntAct: EBI-25908435; Score: 0.56
DE  Interaction: B7Z3E8; IntAct: EBI-25908427; Score: 0.56
DE  Interaction: Q96MW5; IntAct: EBI-25908467; Score: 0.56
DE  Interaction: A1L190; IntAct: EBI-25908655; Score: 0.56
DE  Interaction: Q6DKI2; IntAct: EBI-25908663; Score: 0.56
DE  Interaction: Q7Z6I5; IntAct: EBI-25908639; Score: 0.56
DE  Interaction: Q8IWT0; IntAct: EBI-25908631; Score: 0.56
DE  Interaction: P58304; IntAct: EBI-25908623; Score: 0.56
DE  Interaction: Q8N6F8; IntAct: EBI-25908615; Score: 0.56
DE  Interaction: Q6P597; IntAct: EBI-25908607; Score: 0.56
DE  Interaction: Q86WT6; IntAct: EBI-25908599; Score: 0.56
DE  Interaction: Q96DX5; IntAct: EBI-25908591; Score: 0.56
DE  Interaction: Q8NEZ2; IntAct: EBI-25908583; Score: 0.56
DE  Interaction: Q8NDH6; IntAct: EBI-25908567; Score: 0.56
DE  Interaction: Q6ZMI0; IntAct: EBI-25908559; Score: 0.56
DE  Interaction: Q96A04; IntAct: EBI-25908551; Score: 0.56
DE  Interaction: Q96MN9; IntAct: EBI-25908543; Score: 0.56
DE  Interaction: Q96CS2; IntAct: EBI-25908535; Score: 0.56
DE  Interaction: Q9UII2; IntAct: EBI-25908527; Score: 0.56
DE  Interaction: Q8N4C7; IntAct: EBI-25908647; Score: 0.56
DE  Interaction: Q93009; IntAct: EBI-30844216; Score: 0.44
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0042802;
GO  GO:0008139;
GO  GO:0044877;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0006913;
GO  GO:0015031;
GO  GO:0042306;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P70581};
SQ  MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGG
SQ  TNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTA
SQ  TTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSK
SQ  ALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELK
SQ  NAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALA
SQ  AQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGP
SQ  QPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGI
SQ  TASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR
//