ID  Q9BXJ8;
PN  Ion channel TACAN;
GN  TMEM120A;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}.
DR  UNIPROT: Q9BXJ8;
DR  UNIPROT: Q86TE9;
DR  UNIPROT: Q8N6P1;
DR  PDB: 7CXR;
DR  PDB: 7F3T;
DR  PDB: 7F3U;
DR  PDB: 7F6V;
DR  PDB: 7N7P;
DR  Pfam: PF07851;
DR  OMIM: 616550;
DR  DisGeNET: 83862;
DE  Function: Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229). {ECO:0000250|UniProtKB:Q8C1E7, ECO:0000269|PubMed:26024229}.
DE  Reference Proteome: Yes;
DE  Interaction: A0PK00; IntAct: EBI-11898690; Score: 0.00
DE  Interaction: Q15125; IntAct: EBI-22754310; Score: 0.56
DE  Interaction: Q5JX71; IntAct: EBI-24660892; Score: 0.56
DE  Interaction: P17174; IntAct: EBI-737777; Score: 0.00
DE  Interaction: Q0WED3; IntAct: EBI-2853354; Score: 0.00
DE  Interaction: P36873; IntAct: EBI-4311720; Score: 0.37
DE  Interaction: P06460; IntAct: EBI-11723082; Score: 0.35
DE  Interaction: P06792; IntAct: EBI-11724527; Score: 0.35
DE  Interaction: P36895; IntAct: EBI-11008521; Score: 0.35
DE  Interaction: O55143; IntAct: EBI-11062077; Score: 0.35
DE  Interaction: P32856; IntAct: EBI-24487399; Score: 0.56
DE  Interaction: Q16623; IntAct: EBI-24508438; Score: 0.56
DE  Interaction: Q9NPE6; IntAct: EBI-22744045; Score: 0.56
DE  Interaction: Q13323; IntAct: EBI-22746810; Score: 0.56
DE  Interaction: Q9Y394; IntAct: EBI-22755933; Score: 0.56
DE  Interaction: Q96MV8; IntAct: EBI-22756449; Score: 0.56
DE  Interaction: Q9H6H4; IntAct: EBI-22759718; Score: 0.56
DE  Interaction: Q6PEY1; IntAct: EBI-22760479; Score: 0.56
DE  Interaction: Q53TN4; IntAct: EBI-24668256; Score: 0.56
DE  Interaction: Q9NY72; IntAct: EBI-23746487; Score: 0.56
DE  Interaction: Q13520; IntAct: EBI-24706237; Score: 0.56
DE  Interaction: Q8N386; IntAct: EBI-24713800; Score: 0.56
DE  Interaction: Q6ZUI0; IntAct: EBI-24734735; Score: 0.56
DE  Interaction: Q7Z5P4; IntAct: EBI-23899898; Score: 0.56
DE  Interaction: Q9NUH8; IntAct: EBI-23916710; Score: 0.56
DE  Interaction: Q8WUV1; IntAct: EBI-24575430; Score: 0.56
DE  Interaction: Q53FV1; IntAct: EBI-24644037; Score: 0.56
DE  Interaction: Q53FP2; IntAct: EBI-24644818; Score: 0.56
DE  Interaction: Q9Y320; IntAct: EBI-25169004; Score: 0.56
DE  Interaction: O15243; IntAct: EBI-24774713; Score: 0.56
DE  Interaction: Q8N661; IntAct: EBI-24776791; Score: 0.56
DE  Interaction: Q15155; IntAct: EBI-11914331; Score: 0.00
DE  Interaction: Q969V3; IntAct: EBI-11925943; Score: 0.00
DE  Interaction: Q9NXU5; IntAct: EBI-11930605; Score: 0.00
DE  Interaction: Q9NRZ7; IntAct: EBI-11930596; Score: 0.00
DE  Interaction: Q9H1A3; IntAct: EBI-11931199; Score: 0.00
DE  Interaction: Q9NRX5; IntAct: EBI-11933960; Score: 0.00
DE  Interaction: O00322; IntAct: EBI-21504674; Score: 0.35
DE  Interaction: Q9GZM5; IntAct: EBI-21509346; Score: 0.35
DE  Interaction: Q6P5W5; IntAct: EBI-21515976; Score: 0.35
DE  Interaction: Q9H5K3; IntAct: EBI-21516902; Score: 0.35
DE  Interaction: Q9UHP7; IntAct: EBI-21517465; Score: 0.35
DE  Interaction: O60512; IntAct: EBI-21566019; Score: 0.35
DE  Interaction: Q5VXT5; IntAct: EBI-21760866; Score: 0.35
DE  Interaction: P06576; IntAct: EBI-21800967; Score: 0.35
DE  Interaction: Q9NZH0; IntAct: EBI-20808301; Score: 0.37
DE  Interaction: P25105; IntAct: EBI-20811194; Score: 0.37
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005637;
GO  GO:0005886;
GO  GO:0005216;
GO  GO:0050966;
GO  GO:0045444;
GO  GO:0034220;
GO  GO:0051291;
GO  GO:0051260;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQNNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAA
SQ  QELENQMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVT
SQ  DAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYY
SQ  QSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLAQDPQCKEWQVLMCGFPFLLLFLG
SQ  NFFTTLRVVHHKFHSQRHGSKKD
//