ID  Q9BY64;
PN  UDP-glucuronosyltransferase 2B28;
GN  UGT2B28;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11300766}.
DR  UNIPROT: Q9BY64;
DR  UNIPROT: B5BUM0;
DR  UNIPROT: Q9BY62;
DR  UNIPROT: Q9BY63;
DR  Pfam: PF00201;
DR  PROSITE: PS00375;
DR  OMIM: 606497;
DR  DisGeNET: 54490;
DE  Function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766). {ECO:0000269|PubMed:11300766}. [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity. {ECO:0000269|PubMed:11300766}.
DE  Reference Proteome: Yes;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005640;
GO  GO:0048471;
GO  GO:0015020;
GO  GO:0052695;
GO  GO:0008210;
GO  GO:0008202;
GO  GO:0052697;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTS
SQ  LTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELL
SQ  AALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
SQ  GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAER
SQ  ANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQP
SQ  DNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
SQ  RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD
//