ID  Q9BZF1;
PN  Oxysterol-binding protein-related protein 8;
GN  OSBPL8;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:17991739}. Nucleus membrane {ECO:0000269|PubMed:21698267}. Note=The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). {ECO:0000305|PubMed:26206935}. [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26206935}; Single-pass membrane protein. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:26206935}.
DR  UNIPROT: Q9BZF1;
DR  UNIPROT: A8K1T2;
DR  UNIPROT: E9PE66;
DR  UNIPROT: E9PE68;
DR  UNIPROT: Q52LQ3;
DR  UNIPROT: Q68D75;
DR  UNIPROT: Q8WXP8;
DR  UNIPROT: Q9P277;
DR  PDB: 1V88;
DR  PDB: 5U77;
DR  PDB: 5U78;
DR  Pfam: PF01237;
DR  Pfam: PF00169;
DR  PROSITE: PS01013;
DR  PROSITE: PS50003;
DR  OMIM: 606736;
DR  DisGeNET: 114882;
DE  Function: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25- hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.
DE  Reference Proteome: Yes;
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: Q12800; IntAct: EBI-2684046; Score: 0.00
DE  Interaction: A0A2U2H272; IntAct: EBI-2846189; Score: 0.00
DE  Interaction: Q7ARD3; IntAct: EBI-2862180; Score: 0.00
DE  Interaction: Q13501; IntAct: EBI-3197899; Score: 0.35
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: Q77M19; IntAct: EBI-6270503; Score: 0.35
DE  Interaction: P57078; IntAct: EBI-12503575; Score: 0.35
DE  Interaction: Q9Y3E0; IntAct: EBI-11161387; Score: 0.35
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q96GX1; IntAct: EBI-11375285; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: O36551; IntAct: EBI-14062552; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q8IZF4; IntAct: EBI-21536448; Score: 0.35
DE  Interaction: P16070; IntAct: EBI-21554944; Score: 0.35
DE  Interaction: P47900; IntAct: EBI-21566266; Score: 0.35
DE  Interaction: Q8WWF5; IntAct: EBI-21589535; Score: 0.35
DE  Interaction: Q96FT7; IntAct: EBI-21589962; Score: 0.35
DE  Interaction: P43115; IntAct: EBI-21607127; Score: 0.35
DE  Interaction: P34741; IntAct: EBI-21628438; Score: 0.35
DE  Interaction: Q92838; IntAct: EBI-21651770; Score: 0.35
DE  Interaction: Q86W33; IntAct: EBI-21657892; Score: 0.35
DE  Interaction: Q9H1C3; IntAct: EBI-21662351; Score: 0.35
DE  Interaction: Q9UBU6; IntAct: EBI-21677026; Score: 0.35
DE  Interaction: P32249; IntAct: EBI-21703149; Score: 0.35
DE  Interaction: Q8TCT7; IntAct: EBI-21710636; Score: 0.35
DE  Interaction: P43119; IntAct: EBI-21748886; Score: 0.35
DE  Interaction: Q9GZQ4; IntAct: EBI-21806349; Score: 0.35
DE  Interaction: Q9H0X9; IntAct: EBI-16165776; Score: 0.40
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: P11279; IntAct: EBI-16795318; Score: 0.27
DE  Interaction: Q16778; IntAct: EBI-20899844; Score: 0.40
DE  Interaction: O14776; IntAct: EBI-20932072; Score: 0.40
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: O15524; IntAct: EBI-25373793; Score: 0.35
DE  Interaction: Q8N5H7; IntAct: EBI-25374973; Score: 0.35
DE  Interaction: O15530; IntAct: EBI-25375702; Score: 0.53
DE  Interaction: Q92934; IntAct: EBI-25378368; Score: 0.35
DE  Interaction: P05771; IntAct: EBI-25379671; Score: 0.35
DE  Interaction: Q96R06; IntAct: EBI-25466806; Score: 0.60
DE  Interaction: Q9UKV5; IntAct: EBI-25770556; Score: 0.35
DE  Interaction: Q2TAZ0; IntAct: EBI-26443127; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-26610537; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: A0A0H3NFP4; IntAct: EBI-27055788; Score: 0.27
DE  Interaction: A0A0H3NF08; IntAct: EBI-27055973; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: Q8N488; IntAct: EBI-27110926; Score: 0.35
DE  Interaction: P19784; IntAct: EBI-28934542; Score: 0.35
DE  Interaction: P43405; IntAct: EBI-28935283; Score: 0.35
DE  Interaction: Q15746; IntAct: EBI-28941345; Score: 0.35
DE  Interaction: Q8NCB2; IntAct: EBI-28943408; Score: 0.35
DE  Interaction: Q9Y2K2; IntAct: EBI-28947183; Score: 0.35
DE  Interaction: P08922; IntAct: EBI-32719572; Score: 0.35
DE  Interaction: Q9UM73; IntAct: EBI-32719830; Score: 0.27
DE  Interaction: Q16832; IntAct: EBI-32720227; Score: 0.27
DE  Interaction: P29322; IntAct: EBI-32721175; Score: 0.27
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
DE  Interaction: P17948; IntAct: EBI-32722433; Score: 0.27
DE  Interaction: P35916; IntAct: EBI-32722728; Score: 0.27
DE  Interaction: P08069; IntAct: EBI-32722947; Score: 0.27
DE  Interaction: P06213; IntAct: EBI-32723092; Score: 0.27
DE  Interaction: Q16288; IntAct: EBI-32724526; Score: 0.27
DE  Interaction: P07949; IntAct: EBI-32725031; Score: 0.27
GO  GO:0032541;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0015485;
GO  GO:0070273;
GO  GO:0001786;
GO  GO:0140343;
GO  GO:0005548;
GO  GO:0032934;
GO  GO:0015248;
GO  GO:0032148;
GO  GO:0045444;
GO  GO:0030336;
GO  GO:0010891;
GO  GO:0036150;
GO  GO:0015914;
GO  GO:0046326;
GO  GO:0046628;
GO  GO:0051897;
GO  GO:0090204;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MEGGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKED
SQ  ISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGT
SQ  LKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPS
SQ  SYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQH
SQ  FKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVS
SQ  EENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGL
SQ  KKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFL
SQ  NRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWD
SQ  SEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDR
SQ  KTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYSSP
SQ  EPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPATDYFLQQKDYFIIFLLILL
SQ  QVIINFMFK
//