ID  Q9BZF3;
PN  Oxysterol-binding protein-related protein 6;
GN  OSBPL6;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:26941018, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:26941018}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8BXR9}.
DR  UNIPROT: Q9BZF3;
DR  UNIPROT: B4DTW1;
DR  UNIPROT: C4AMC0;
DR  UNIPROT: C4AME4;
DR  UNIPROT: D3DPF6;
DR  UNIPROT: D3DPF7;
DR  UNIPROT: Q4ZG68;
DR  UNIPROT: Q53T68;
DR  UNIPROT: Q59H61;
DR  UNIPROT: Q7Z4Q1;
DR  UNIPROT: Q86V84;
DR  UNIPROT: Q8N9T0;
DR  UNIPROT: Q96SR1;
DR  Pfam: PF01237;
DR  Pfam: PF15409;
DR  PROSITE: PS01013;
DR  PROSITE: PS50003;
DR  OMIM: 606734;
DR  DisGeNET: 114880;
DE  Function: Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9BVL2; IntAct: EBI-21639380; Score: 0.35
DE  Interaction: P53350; IntAct: EBI-2372594; Score: 0.53
DE  Interaction: Q9Q2G4; IntAct: EBI-6174875; Score: 0.56
DE  Interaction: O95292; IntAct: EBI-8801774; Score: 0.35
DE  Interaction: Q96IW2; IntAct: EBI-10698427; Score: 0.37
DE  Interaction: Q9H6Z9; IntAct: EBI-12503146; Score: 0.35
DE  Interaction: Q9P0L0; IntAct: EBI-11120309; Score: 0.35
DE  Interaction: O43166; IntAct: EBI-11900942; Score: 0.00
DE  Interaction: O60307; IntAct: EBI-11902057; Score: 0.00
DE  Interaction: O75044; IntAct: EBI-11902776; Score: 0.00
DE  Interaction: O75420; IntAct: EBI-11903362; Score: 0.00
DE  Interaction: P21359; IntAct: EBI-11906164; Score: 0.00
DE  Interaction: P30307; IntAct: EBI-11907486; Score: 0.00
DE  Interaction: P56524; IntAct: EBI-11909660; Score: 0.00
DE  Interaction: Q08AD1; IntAct: EBI-11911957; Score: 0.00
DE  Interaction: Q6Y7W6; IntAct: EBI-11919103; Score: 0.00
DE  Interaction: Q86X27; IntAct: EBI-11920973; Score: 0.00
DE  Interaction: Q9BQK8; IntAct: EBI-11929945; Score: 0.00
DE  Interaction: Q9ULR3; IntAct: EBI-11930929; Score: 0.00
DE  Interaction: Q9BST9; IntAct: EBI-11930920; Score: 0.00
DE  Interaction: Q8TEH3; IntAct: EBI-11930911; Score: 0.00
DE  Interaction: Q8IVT5; IntAct: EBI-11930902; Score: 0.00
DE  Interaction: Q5VZ89; IntAct: EBI-11930893; Score: 0.00
DE  Interaction: Q5TCZ1; IntAct: EBI-11930884; Score: 0.00
DE  Interaction: O60573; IntAct: EBI-11930875; Score: 0.00
DE  Interaction: Q9NQT8; IntAct: EBI-11933394; Score: 0.00
DE  Interaction: Q9NRR6; IntAct: EBI-11933906; Score: 0.00
DE  Interaction: Q9P244; IntAct: EBI-11935434; Score: 0.00
DE  Interaction: Q9P2M7; IntAct: EBI-11936126; Score: 0.00
DE  Interaction: Q9UHB6; IntAct: EBI-11936854; Score: 0.00
DE  Interaction: Q9ULJ3; IntAct: EBI-11938866; Score: 0.00
DE  Interaction: Q9Y3M2; IntAct: EBI-11941204; Score: 0.00
DE  Interaction: Q9Y597; IntAct: EBI-11942318; Score: 0.00
DE  Interaction: Q76RG8; IntAct: EBI-14063537; Score: 0.35
DE  Interaction: P22732; IntAct: EBI-21554490; Score: 0.35
DE  Interaction: Q96JJ6; IntAct: EBI-21570881; Score: 0.35
DE  Interaction: Q96IQ9; IntAct: EBI-21636586; Score: 0.35
DE  Interaction: O14965; IntAct: EBI-21639587; Score: 0.35
DE  Interaction: Q9NYP9; IntAct: EBI-21663541; Score: 0.35
DE  Interaction: Q9NZM5; IntAct: EBI-21744295; Score: 0.35
DE  Interaction: O95159; IntAct: EBI-21768155; Score: 0.35
DE  Interaction: Q8N5I2; IntAct: EBI-21770417; Score: 0.35
DE  Interaction: Q15363; IntAct: EBI-21784458; Score: 0.35
DE  Interaction: Q13077; IntAct: EBI-21795913; Score: 0.35
DE  Interaction: P53004; IntAct: EBI-21805374; Score: 0.35
DE  Interaction: P20160; IntAct: EBI-21867396; Score: 0.35
DE  Interaction: A1L0T0; IntAct: EBI-21879063; Score: 0.35
DE  Interaction: P27348; IntAct: EBI-21902679; Score: 0.35
DE  Interaction: P31946; IntAct: EBI-21903886; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: Q04917; IntAct: EBI-21907689; Score: 0.35
DE  Interaction: P63104; IntAct: EBI-21909838; Score: 0.35
DE  Interaction: Q16778; IntAct: EBI-20913574; Score: 0.40
DE  Interaction: P0DOF2; IntAct: EBI-25607852; Score: 0.35
DE  Interaction: O14901; IntAct: EBI-25906103; Score: 0.56
DE  Interaction: Q9GZQ8; IntAct: EBI-30831552; Score: 0.44
GO  GO:0005829;
GO  GO:0031901;
GO  GO:0005789;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0097038;
GO  GO:0005886;
GO  GO:0015485;
GO  GO:0032934;
GO  GO:0015248;
GO  GO:0006699;
GO  GO:0032374;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQ
SQ  TNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYH
SQ  LKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPAT
SQ  CTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSV
SQ  SKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEK
SQ  EKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQV
SQ  ANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLP
SQ  APCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTY
SQ  FRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKY
SQ  GDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEG
SQ  LYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQR
SQ  SRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW
//