ID  Q9C5H9;
PN  Gamma-tubulin complex component 2;
GN  GCP2;
OS  3702;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9BSJ2}. Nucleus envelope. Cytoplasm. Cytoplasm, cell cortex. Note=Associated to motile complexes in the cytosol that transiently stabilized at fixed locations in the cell cortex (e.g. along the outer periclinal edge of newly formed crosswalls) from which microtubules grow away prior to microtubules nucleation. Colocalizes with gamma-tubulin at the nuclear surface where microtubules are nucleated.
DR  UNIPROT: Q9C5H9;
DR  UNIPROT: F4KGZ8;
DR  UNIPROT: Q9LF43;
DR  Pfam: PF04130;
DR  Pfam: PF17681;
DE  Function: Gamma-tubulin complex is necessary for microtubule nucleation at the microtubule organizing centers (MTOCs). Required for the positioning of the gamma-tubulin-containing complex on pre-existing microtubules and for the proper organization of cortical arrays. {ECO:0000269|PubMed:19509058, ECO:0000269|PubMed:20935636}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9LT56; IntAct: EBI-4521088; Score: 0.37
GO  GO:0005938;
GO  GO:0055028;
GO  GO:0005737;
GO  GO:0000923;
GO  GO:0000930;
GO  GO:0008275;
GO  GO:0005635;
GO  GO:0000922;
GO  GO:0043015;
GO  GO:0031122;
GO  GO:0048229;
GO  GO:0033566;
GO  GO:0051321;
GO  GO:0007020;
GO  GO:0000278;
GO  GO:0090063;
GO  GO:0051225;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MESMTPISCPTTPRWNQDRPFLTGRFHQETRASSKFADSKRFTLDSSSSGVEQAIGCYDTPVQELIVIDDLLSALVGIEG
SQ  RYISIKRFHGKEDSIAFQVDPSMDLALQELAKRIFPLCEYYLLIDQFVESSSQFKNGLVNHAFAAALRALLLDYQAMVAQ
SQ  LEHQFRLGRLSIQGLWFYCQPMMGSMRALAAVIQQASTKQFVGSGVLNLLQSQAKAMAGDNSVRSLLEKMTECASNAYLS
SQ  ILERWVYEGIIDDPYGEFFIAENRSLKKESLSQDSTAKYWSQRYSLKDTIPGFLANIAATILTTGKYLNVMRECGHNVQV
SQ  PISERSKLTIFGSNHHYLECIKAAHEFASIELVNLIKDKYDLVGRLRSIKHYLLLDQGDFLVHFMDIAREELNKKVHEIS
SQ  VEKLQSLLDLALRTTAAAADPRHEDLTCCVDRASLLTTLGMHKDTDSNSIEDPMSITGLETFSLSYKVQWPLSIVISKKA
SQ  LSKYQLIFRFLFHCKHVERQLCGAWQIHQGIRSMNSKGTAILRSSLLCRSMLKFISSLLHYLTFEVLEPNWHVMHDRLQS
SQ  TRSVDEVIQHHDFFLDKCLRGCLLLLPDVLKKMEKLKSVCLQYAAATQWLISSSIDINSQSHPQKTMIRDTTVTESIFNF
SQ  EREFNSELQSLGPVLSKGSQAEPYLTHLSQWILGVSKE
//