ID  Q9CA42;
PN  Protein CROWDED NUCLEI 3;
GN  CRWN3;
OS  3702;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0180;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:F4HRT5}; Peripheral membrane protein {ECO:0000250|UniProtKB:F4HRT5}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23396599}. Cytoplasm {ECO:0000269|PubMed:23396599}. Nucleus lamina {ECO:0000250|UniProtKB:F4HRT5}. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (By similarity). Punctate or bundle-like structures are detected, especially in trichomes where bundle-shape localization pattern along the long axis of the nucleus is observed. During prometaphase to anaphase, localized diffusely in the cytoplasm. Later transferred from the cytoplasm to the chromatin surface, preferentially assembling to the distal surface of the chromatin. Relocalized to the nuclear periphery during late telophase (PubMed:23396599). {ECO:0000250|UniProtKB:F4HRT5, ECO:0000269|PubMed:23396599}.
DR  UNIPROT: Q9CA42;
DE  Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity). Required for nucleus structure organization (e.g. size and shape) (PubMed:24308514, PubMed:23396599). {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:23396599, ECO:0000269|PubMed:24308514}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9SB04; IntAct: EBI-1999431; Score: 0.37
DE  Interaction: Q9ZWS7; IntAct: EBI-1999571; Score: 0.37
GO  GO:0005737;
GO  GO:0005652;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0009506;
GO  GO:0006997;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:F4HRT5};
SQ  MFTPQRNRWPETDRKGKAIAFSDEIITPPPQRVLLREDDDWQKFKEVGLLDEASLERKDRDALIEKILKLEKELFDYQHN
SQ  MGLLLIEKKQWTSTNNELQQAYDEAMEMLKREKTSNAITLNEADKREENLRKALIDEKQFVAELENDLKYWQREHSVVKS
SQ  TSEAKLEEANALVIGMKEKALEVDRERAIAEEKFSVMNRKSSELERKLKEVETREKVHQREHLSLVTEREAHEAVFYKQR
SQ  EDLQEWEKKLTLEEDRLSEVKRSINHREERVMENERTIEKKEKILENLQQKISVAKSELTEKEESIKIKLNDISLKEKDF
SQ  EAMKAKVDIKEKELHEFEENLIEREQMEIGKLLDDQKAVLDSRRREFEMELEQMRRSLDEELEGKKAEIEQLQVEISHKE
SQ  EKLAKREAALEKKEEGVKKKEKDLDARLKTVKEKEKALKAEEKKLHMENERLLEDKECLRKLKDEIEEIGTETTKQESRI
SQ  REEHESLRITKEERVEFLRLQSELKQQIDKVKQEEELLLKEREELKQDKERFEKEWEALDKKRANITREQNEVAEENEKL
SQ  RNLQISEKHRLKREEMTSRDNLKRELDGVKMQKESFEADMEDLEMQKRNLDMEFQRQEEAGERDFNERARTYEKRSQEEL
SQ  DNINYTKKLAQREMEEMQYEKLALEREREQISVRKKLLKEQEAEMHKDITELDVLRSSLKEKRKEFICERERFLVFLEKL
SQ  KSCSSCGEITENFVLSDLRLPDVEDGDKRFGKQKLKAEEALNISPSAENSKRTSLLGKIASKLLSISPIGKTDKVTDLGI
SQ  TVKLPESSQPDDSLDRVSGEDHEPSATEQSFTDSRIQEGPEGSLQSEMKSDKPRRGRGRGRGRGKSVRGRSQATKAVSRD
SQ  SKPSDGETPRKRQREQTSRITESEQAAGDSDEGVDSITTGGRRKKRQIAVPVSQTPGQTRYQLRRHRNVGTEEDKAQASK
SQ  GATEKQERVNDDIRKVPSPKETRTPPEGENRENGKAEVLVETVTHEEIVTVETETVFKVNNTGKNPVEDPQLEVGGSGEI
SQ  REHGEEDDENISMIEEENEGEEEEETERQGNDASIGKKIWVFFTT
//