ID  Q9CR67;
PN  Transmembrane protein 33;
GN  Tmem33;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31048699}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:P57088}. Nucleus envelope {ECO:0000250|UniProtKB:P57088}. Note=Co-localizes with RTN4 at the ER sheets. {ECO:0000250|UniProtKB:P57088}.
DR  UNIPROT: Q9CR67;
DR  UNIPROT: Q544Q3;
DR  UNIPROT: Q9D3M3;
DR  UNIPROT: Q9DAV4;
DR  Pfam: PF03661;
DE  Function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity). {ECO:0000250|UniProtKB:P57088, ECO:0000269|PubMed:31048699}.
DE  Reference Proteome: Yes;
DE  Interaction: Q3TBT3; IntAct: EBI-10729637; Score: 0.35
DE  Interaction: A0A0F6B1Q8; IntAct: EBI-27035518; Score: 0.35
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0030176;
GO  GO:0042470;
GO  GO:0005635;
GO  GO:0071786;
GO  GO:0045087;
GO  GO:0061024;
GO  GO:1903896;
GO  GO:1903899;
GO  GO:1903371;
GO  GO:0034976;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLS
SQ  RAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSFLDKLSTNQQNILKFI
SQ  ACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHIIMKPSCPLFVRRLCLQSIAFIS
SQ  RLAPTVA
//