ID  Q9D0Z3;
PN  Transmembrane protein 53;
GN  Tmem53;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Nucleus outer membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:20091084}; Single-pass membrane protein {ECO:0000305}.
DR  UNIPROT: Q9D0Z3;
DR  UNIPROT: A2AE66;
DR  UNIPROT: Q8VDW5;
DR  UNIPROT: Q9DAF0;
DR  Pfam: PF05705;
DE  Function: Negatively regulates bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins. {ECO:0000269|PubMed:33824347}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0005640;
GO  GO:0030514;
GO  GO:0030279;
GO  GO:0045668;
GO  GO:0046822;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MASAELDYSIEIPDQPCWSQKNRQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLG
SQ  IPSLRVIAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSNLIGALRALATI
SQ  LERRPAVLRLLLLAAFALVVILFHFLLAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEARLAHQVM
SQ  VRGVDFVSSAHVSHLRDYPTYYTSLCVDFMHNCVQC
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