ID  Q9D304;
PN  E3 ubiquitin-protein ligase RNF128;
GN  Rnf128;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Endomembrane system {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A. {ECO:0000250}.
DR  UNIPROT: Q9D304;
DR  UNIPROT: Q3UJY0;
DR  UNIPROT: Q9CVG1;
DR  UNIPROT: Q9DBN3;
DR  UNIPROT: Q9JJF8;
DR  Pfam: PF02225;
DR  Pfam: PF13639;
DR  PROSITE: PS50089;
DE  Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity). {ECO:0000250, ECO:0000269|PubMed:12435366, ECO:0000269|PubMed:12705856}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005783;
GO  GO:0005794;
GO  GO:0016021;
GO  GO:0005770;
GO  GO:0048471;
GO  GO:0046872;
GO  GO:0061630;
GO  GO:0001818;
GO  GO:0031647;
GO  GO:0006511;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGPPPGIGVYCRGGCGAARLLAWCFLLALSPHAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPV
SQ  SGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNFPGTRNEVIPMSH
SQ  PGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQ
SQ  SRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCD
SQ  ILKALGIEVDVEDGSVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEANSVAV
SQ  DVVPHVDNPTFEEDETPDQEAAVREIKS
//