ID  Q9DBS1;
PN  Transmembrane protein 43;
GN  Tmem43;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BTV4}. Nucleus inner membrane {ECO:0000269|PubMed:18230648}; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen. {ECO:0000269|PubMed:18230648}.
DR  UNIPROT: Q9DBS1;
DR  Pfam: PF07787;
DE  Function: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (PubMed:18230648). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF- kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). {ECO:0000250|UniProtKB:Q9BTV4, ECO:0000269|PubMed:18230648}.
DE  Reference Proteome: Yes;
DE  Interaction: P68510; IntAct: EBI-8586548; Score: 0.35
DE  Interaction: Q8BP00; IntAct: EBI-4283417; Score: 0.35
GO  GO:0005788;
GO  GO:0005789;
GO  GO:0005794;
GO  GO:0005639;
GO  GO:0005637;
GO  GO:0042802;
GO  GO:0043621;
GO  GO:0045087;
GO  GO:0071763;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSV
SQ  APENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRN
SQ  FDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVR
SQ  VSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMF
SQ  MGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE
//