ID  Q9DBS9;
PN  Oxysterol-binding protein-related protein 3;
GN  Osbpl3;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:30028970}. Cell membrane {ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:Q9H4L5}. Nucleus membrane {ECO:0000250|UniProtKB:Q9H4L5}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000269|PubMed:30028970}.
DR  UNIPROT: Q9DBS9;
DR  UNIPROT: E9QNI5;
DR  Pfam: PF01237;
DR  Pfam: PF15409;
DR  PROSITE: PS01013;
DR  PROSITE: PS50003;
DE  Function: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol. {ECO:0000250|UniProtKB:Q9H4L5}.
DE  Reference Proteome: Yes;
DE  Interaction: Q80YT7; IntAct: EBI-16732484; Score: 0.35
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0032433;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0097038;
GO  GO:0005886;
GO  GO:0015485;
GO  GO:0032934;
GO  GO:0015248;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMTYTQEPPVQKGFLLKKRKWPLKGWHKRFFCLEKGIL
SQ  KYAKSQADIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEELFDEWVSKLRHHRMYRQNEIAMFPRDVNH
SQ  FFSGSSVTDSAPGVFESVSSRKRSSLSKQNSFPPGSNLSFSCGGDTRVPFWLQSSEDMEKCSKDMAHCHAYLLEMSQLLE
SQ  SMDVLHRTYSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQEDLCHVAHKVYFALRSAFN
SQ  SISVEREKLKQLMELDTSPSPSAQVVGLKHALSSALAQNTDLKERLRRIHAESLLLDPPAVPKPGDNLAEENSRDEGRAL
SQ  VHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLESSGEARSKR
SQ  RTSLPAPGPNTSSVSLWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAAFAISA
SQ  YASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVFWQDVRWKNKFWGKSMEIVPIGTTHV
SQ  TLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFG
SQ  KWHESIYCGGASSSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRI
SQ  EKLQRERRRVLEENGVEHQPRFFRKSSDDAWVSNGTYLELRKDLGFSKLDHPVLW
//