ID  Q9DCG9;
PN  Multifunctional methyltransferase subunit TRM112-like protein;
GN  Trmt112;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9UI30}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UI30}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. {ECO:0000250|UniProtKB:Q9UI30}.
DR  UNIPROT: Q9DCG9;
DR  UNIPROT: Q91YP8;
DR  UNIPROT: Q9D1N6;
DR  Pfam: PF03966;
DE  Function: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:20606008, PubMed:26797129). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (By similarity). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:20606008, PubMed:26797129). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)- methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (By similarity). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (By similarity). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). {ECO:0000250|UniProtKB:Q9UI30, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129}.
DE  Reference Proteome: Yes;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0046982;
GO  GO:0008276;
GO  GO:0034968;
GO  GO:0018364;
GO  GO:2000234;
GO  GO:0070476;
GO  GO:0031167;
GO  GO:0030488;
GO  GO:0002940;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKLLTHNLLSSHVRGVGTRGFPLRLQATEVRINPVEFNPEFVARMIPKVEWAALVQAADTLNLAEVPKEPTEGYEHDETF
SQ  LRKMHHVLLEVDVLEGTLQCPESGRLFPISRGIPNMLLNDEETET
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