ID  Q9EPM5;
PN  Syncoilin;
GN  Sync;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11053421, ECO:0000269|PubMed:11694502, ECO:0000269|PubMed:17629480}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern. {ECO:0000269|PubMed:11053421, ECO:0000269|PubMed:11694502, ECO:0000269|PubMed:17629480}.
DR  UNIPROT: Q9EPM5;
DR  UNIPROT: Q3KP79;
DR  UNIPROT: Q3TKN1;
DR  UNIPROT: Q3TUH9;
DR  UNIPROT: Q8C4J4;
DR  UNIPROT: Q9CT88;
DR  Pfam: PF00038;
DR  PROSITE: PS51842;
DE  Function: Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {ECO:0000269|PubMed:11694502, ECO:0000269|PubMed:18367591}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9Y4J8; IntAct: EBI-7424047; Score: 0.54
DE  Interaction: P31001; IntAct: EBI-8031285; Score: 0.46
DE  Interaction: P15331; IntAct: EBI-27023883; Score: 0.46
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005882;
GO  GO:0031594;
GO  GO:0048471;
GO  GO:0042383;
GO  GO:0030018;
GO  GO:0045103;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MASPEPLRGGDGARASREPHTEASFPLQESESPKEAKTFNPEATLSLEGTVNLEDILYLGASGDFEESFYEEEYEKPALT
SQ  LFIDESRQPDEALGLEEPVRPEEMLSVEESVTPDEVQISEQPVEPAKSPTACEGEMVATEGSLPAQPIPNTEEDPLSVED
SQ  LERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTK
SQ  ECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENL
SQ  MAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYR
SQ  EQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQADAPTSQAGGVEAQSPGTV
//