ID  Q9ES63;
PN  Ubiquitin carboxyl-terminal hydrolase 29;
GN  Usp29;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:32457395}. Note=Localizes to perinuclear region in response to herpes simplex virus-1 (HSV-1) infection. {ECO:0000269|PubMed:32457395}.
DR  UNIPROT: Q9ES63;
DR  UNIPROT: C6EQG1;
DR  Pfam: PF00443;
DR  Pfam: PF16674;
DR  PROSITE: PS00972;
DR  PROSITE: PS00973;
DR  PROSITE: PS50235;
DE  Function: Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization. {ECO:0000269|PubMed:32457395}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0051607;
GO  GO:0000082;
GO  GO:0045087;
GO  GO:0060340;
GO  GO:0016579;
GO  GO:0071108;
GO  GO:0050821;
GO  GO:0006511;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAHLKINGLVQIRSTNRSKHTRASQWKEAVIEIVERKQKVNLVVSFKLEERRRVFQLGDNVTGVVVSGELGLYHLDLTLR
SQ  DDTSLLIDKLSSADVEHLKSFLDSSTPCESQQPMEPMSSQDDLESSDPFCGEHQEAACGSLNTTPESGTPLSRKMPLSMS
SQ  NTTGGQKRGEKQGRKRKTEPSSSSAEVNKDIPKENTPDQKKKSRRYYSRNRGGKAEKAVTLREQEKRSNWKLEPAFNSKS
SQ  YGRANLDGTILPIATCSDDRDVSIFGLEIITHNGVQSLPDPYLNQLKREGFPNLGNTCYMNSILQSVFGIPTFAKDLLTQ
SQ  GIPWEKVSYDDLIMPLSQLLVLKDIRDVEIKGELLTSVKKSISTVADTFSGNEQNDAHEFLSLCLDQLKLNMEKVNAMWD
SQ  TERRNTCAGSAGTKRFVCPVGANFEFELHSSIICEGCGEATIKTEVSNYLSIDLHHGTKTHPLSIQKSFDLFFTPEKIEH
SQ  NCEKCKNKNSVLKYTLRRLPRVLIVHLKRYQVTTDLLPVKSEQPVEISKYLNISSHCHENRKLPFPLANTSPDVSQGMMP
SQ  GIFNQSMLSKKVISESCDPMVLQVGSSVDAEIQSFQIMYEDEDASEEQQQRGLESGSMLEPELVKTENRILRQKTSLATD
SQ  SMMGDGYSFLPMLCEPLSIQDPGLAEMGLQEVPENPEFKNYEKINIYGKSDGRTNTELSKLYQNHGSRIKGLFLPASLAS
SQ  VSSQEDPEKDLSRSPELQEDDPHSFAFGSDDSKDGEMGDDLQNYRLVSVVSHFGSSPNSGHYVSDVYDFQKQAWLLYSDV
SQ  QVFESSDPSIQENRLNSGYIFFYMHNEIFEELLKKASECKVLSTSKEEKRDIDYFSTLLNGLTYILEEF
//