ID  Q9ESN9;
PN  C-Jun-amino-terminal kinase-interacting protein 3;
GN  Mapk8ip3;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:10629060}. Golgi apparatus {ECO:0000269|PubMed:11106729}. Cytoplasmic vesicle {ECO:0000269|PubMed:11106729}. Cell projection, growth cone {ECO:0000269|PubMed:10629060}. Cell projection, axon {ECO:0000269|PubMed:25944905}. Cell projection, dendrite {ECO:0000250|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells (PubMed:10629060, PubMed:11106729). KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation (By similarity). {ECO:0000250|UniProtKB:E9PSK7, ECO:0000269|PubMed:10629060, ECO:0000269|PubMed:11106729}.
DR  UNIPROT: Q9ESN9;
DR  UNIPROT: Q5D062;
DR  UNIPROT: Q99KU7;
DR  UNIPROT: Q9EQD8;
DR  UNIPROT: Q9ESN7;
DR  UNIPROT: Q9ESN8;
DR  UNIPROT: Q9ESP0;
DR  UNIPROT: Q9JLH2;
DR  UNIPROT: Q9JLH3;
DR  UNIPROT: Q9R0U7;
DR  PDB: 6EJN;
DR  Pfam: PF16471;
DR  Pfam: PF09744;
DR  PROSITE: PS51776;
DR  PROSITE: PS51777;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553). {ECO:0000269|PubMed:10523642, ECO:0000269|PubMed:10629060, ECO:0000269|PubMed:23576431, ECO:0000269|PubMed:25944905, ECO:0000269|PubMed:28259553}.
DE  Reference Proteome: Yes;
DE  Interaction: O88448; IntAct: EBI-297849; Score: 0.68
DE  Interaction: O88447; IntAct: EBI-297849; Score: 0.72
DE  Interaction: P63101; IntAct: EBI-2255635; Score: 0.35
DE  Interaction: P62331; IntAct: EBI-7986308; Score: 0.60
DE  Interaction: P28738; IntAct: EBI-7017356; Score: 0.59
DE  Interaction: Q9ESN9; IntAct: EBI-7017786; Score: 0.40
DE  Interaction: Q9ERE9; IntAct: EBI-7017828; Score: 0.40
DE  Interaction: Q9UQF2; IntAct: EBI-7017807; Score: 0.40
DE  Interaction: Q5S007; IntAct: EBI-6530187; Score: 0.40
DE  Interaction: Q61831; IntAct: EBI-9549479; Score: 0.54
DE  Interaction: Q9WTU6; IntAct: EBI-9549854; Score: 0.40
DE  Interaction: Q91Y86; IntAct: EBI-9549815; Score: 0.40
DE  Interaction: P47809; IntAct: EBI-9549947; Score: 0.50
DE  Interaction: P31938; IntAct: EBI-9550942; Score: 0.50
DE  Interaction: P53349; IntAct: EBI-9550988; Score: 0.50
DE  Interaction: P04049; IntAct: EBI-9637077; Score: 0.50
DE  Interaction: O88704; IntAct: EBI-16730213; Score: 0.35
DE  Interaction: Q80VP2; IntAct: EBI-21018622; Score: 0.35
DE  Interaction: P16056; IntAct: EBI-27118288; Score: 0.35
GO  GO:0030673;
GO  GO:0030424;
GO  GO:1904115;
GO  GO:0044297;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0030425;
GO  GO:0000139;
GO  GO:0030426;
GO  GO:0043005;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005790;
GO  GO:0008432;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0031434;
GO  GO:0031435;
GO  GO:0030159;
GO  GO:0099641;
GO  GO:0061564;
GO  GO:0007411;
GO  GO:0031103;
GO  GO:0030900;
GO  GO:0001701;
GO  GO:0007254;
GO  GO:0048286;
GO  GO:0060425;
GO  GO:0043066;
GO  GO:0046330;
GO  GO:0043507;
GO  GO:0045666;
GO  GO:2001224;
GO  GO:0009791;
GO  GO:0008104;
GO  GO:0050821;
GO  GO:0010468;
GO  GO:0046328;
GO  GO:0007585;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVEL
SQ  ELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE
SQ  YNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRSRKERPTSLNVFPLADGMVRAQMGGKLVPAGDHWHLSDLG
SQ  QLQSSSSYQCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYVSVTKNNKQAREKRNSRNMEV
SQ  QVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLERTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE
SQ  GADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIKEL
SQ  EEELKRVKSEAVTARREPREEVEDVSSYLCTELDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR
SQ  EHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRSYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSAR
SQ  REQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWK
SQ  PHEEDSSNGPKPVPGRDPLTCDREGEGEPKSTHPSPEKKKAKETPEADATSSRVWILTSTLTTSKVVIIDANQPGTIVDQ
SQ  FTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGDVA
SQ  TTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPSSSTQPASENGSESNGTIVQPQVEPSGE
SQ  LSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHL
SQ  MDLGHPHHSIRCMAVVNDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTH
SQ  QHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTR
SQ  PGGIIHVYGDDSSDKAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKL
SQ  KNALVLSGGEGYIDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE
//