ID  Q9EST1;
PN  Gasdermin-A, C-terminal;
GN  Gsdma;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: [Gasdermin-A]: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96QA5}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}. [Gasdermin-A, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
DR  UNIPROT: Q9EST1;
DR  UNIPROT: A3KFN3;
DR  Pfam: PF04598;
DR  Pfam: PF17708;
DE  Function: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. {ECO:0000250|UniProtKB:Q96QA5}. [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)- bisphosphate. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown. {ECO:0000250|UniProtKB:Q96QA5}.
DE  Reference Proteome: Yes;
DE  Interaction: Q6AXH7; IntAct: EBI-6876709; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005546;
GO  GO:0070273;
GO  GO:0001786;
GO  GO:0006915;
GO  GO:0042742;
GO  GO:0070269;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q5Y4Y6};
SQ  MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVHTDYTLLDVLEPGSSPSDPTDSGNFS
SQ  FKNMLDARVEGDVDVPKTVKVKGTAGLSRSSTLEVQTLSVAPTALENLHKERKLSADHPFLKEMRERGENLYVVMEVVET
SQ  LQEVTLERAGKAEGCFSLPFFAPLGLQGSVNHKEAVTIPKGCVLAYRVRQLMVNGKDEWGIPHICNDSMQTFPPGEKPGE
SQ  GKFILIQASDVGEMHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQTLEGALDKGHEVTLEALP
SQ  KDVLLSKDAMDAILYFLGALTVLSEAQQKLLVKSLEKKILPVQLKLVESTMEKNFLQDKEGVFPLQPDLLSSLGEEELIL
SQ  TEALVGLSGLEVQRSGPQYTWDPDTLPHLCALYAGLSLLQLLSKNS
//