ID  Q9FH18;
PN  WPP domain-interacting protein 2;
GN  WIP2;
OS  3702;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:17600715, ECO:0000269|PubMed:22270916}. Nucleus membrane {ECO:0000269|PubMed:17600715}; Single-pass membrane protein {ECO:0000269|PubMed:17600715}; Cytoplasmic side {ECO:0000269|PubMed:17600715}. Note=Targeted to the nuclear envelope (NE) during interphase. Associated to the cell plate during cytokinesis in root tips.
DR  UNIPROT: Q9FH18;
DR  UNIPROT: Q5XUY7;
DR  UNIPROT: Q5XUY8;
DE  Function: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips (PubMed:17600715). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303). {ECO:0000269|PubMed:17600715, ECO:0000269|PubMed:25759303}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8GXA4; IntAct: EBI-1779584; Score: 0.62
DE  Interaction: Q8L7E5; IntAct: EBI-1796676; Score: 0.51
DE  Interaction: Q9C500; IntAct: EBI-1779631; Score: 0.37
DE  Interaction: Q9FF75; IntAct: EBI-11657658; Score: 0.37
DE  Interaction: Q9LE82; IntAct: EBI-1779474; Score: 0.59
DE  Interaction: Q9M651; IntAct: EBI-1779579; Score: 0.37
DE  Interaction: Q9FH18; IntAct: EBI-1779591; Score: 0.55
DE  Interaction: Q9FMH6; IntAct: EBI-1779608; Score: 0.37
DE  Interaction: Q8GW44; IntAct: EBI-11657663; Score: 0.37
GO  GO:0009504;
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0006997;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDLESESSVLESVEDNNGLIGDLDKELNSPVETSPLISKGFGLRKWKRRLRRDLVKDDTSVSMENSKALKRVLSGLVDPN
SQ  AKQMHLPGPEVRQDSVGSVGSVNSVVGFVMGGESYGNGLAFAAGVDSDNSEDRSSTMSHSWDKHRGKVSGGKSVISSGDS
SQ  SQQRKSSVEKSNKLRGERIKIEKENSHSSMESADSRSSNFVFMQGASYSLSSREQGGRRMMDYDDENSDHDAHTSKRKDN
SQ  VEEEEEETEDYSQGDCVEESQIKSNGSSDNLDPLIVAVNSFQTLQEALQKELQKFQELGKEEPITSLHDGGESSSCIHAG
SQ  HEGASEASSSYRFGSEKMGEMELTSLDSEILNLVNNVEHLEIKLEEAKRILEVKETQIRELESTINVSETCNGGTEIGIE
SQ  DIFQQKVEAEIEYIIFSRSVGNLKRRIKLIEEEKTLGLSKLDKAETKAENLKNQAQDLQNHCVEITEIQEVECLKKRAFK
SQ  TTRCLLLQLGLLFILYYSLLPEPEIAVPT
//