ID  Q9FLT0;
PN  Ribonuclease TUDOR 2;
GN  TSN2;
OS  3702;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25736060}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20484005}. Endoplasmic reticulum {ECO:0000269|PubMed:20484005}. Cytoplasmic granule {ECO:0000269|PubMed:25736060}. Note=Accumulates heterogeneously in the cytosol, in patches around the nucleus and in the cell periphery, and relocates transiently to a diffuse pattern in response to salt stress (PubMed:20484005). Accumulates in cytoplasmic stress granules (SGs) and processing bodies (PBs) in response to abiotic stresses (e.g. salt and heat) (PubMed:25736060). {ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25736060}.
DR  UNIPROT: Q9FLT0;
DR  UNIPROT: Q0WLY7;
DR  UNIPROT: Q0WM01;
DR  UNIPROT: Q0WVT1;
DR  Pfam: PF00565;
DR  Pfam: PF00567;
DR  PROSITE: PS50830;
DR  PROSITE: PS50304;
DE  Function: Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress (PubMed:25736060). Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat) (PubMed:25736060). Involved in gibberellic acid (GA) biosynthesis and seed germination (PubMed:20396901). Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway (PubMed:20484005). Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA. Binds GA20OX3 mRNA (By similarity). May inhibit the degradation of mRNAs involved in stress adaptation (PubMed:26237081). {ECO:0000250|UniProtKB:Q8VZG7, ECO:0000269|PubMed:20396901, ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25736060, ECO:0000269|PubMed:26237081}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0010494;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0009506;
GO  GO:0009536;
GO  GO:0016442;
GO  GO:0003729;
GO  GO:0004518;
GO  GO:0003723;
GO  GO:0034605;
GO  GO:0031047;
GO  GO:0009686;
GO  GO:0006402;
GO  GO:0006397;
GO  GO:0010372;
GO  GO:0046686;
GO  GO:0009651;
GO  GO:0009845;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MATGAATENQWLKGRVKAVTSGDCLVITALTHNRAGPPPEKTITLSSLMAPKMARRGGIDEPFAWESREFLRKLCIGKEV
SQ  AFKVDYKVEAIAGREFGSVYLGNENLAKLVVQNGWAKVRRPGQQNQDKVSPYIAELEQLEEQAQQEGFGRWSKVPGAAEA
SQ  SIRNLPPSAVGDSGNFDAMGLLAASKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGLQAPSMGRRQSTQEAVVDPD
SQ  VTATSNGDASAETRGPLTTAQRLAASAASSVEVSSDPFAMEAKYFTELRVLNRDVRIVLEGVDKFNNLIGSVYYSDGDTV
SQ  KDLGLELVENGLAKYVEWSANMLDEEAKKKLKATELQCKKNRVKMWANYVPPASNSKAIHDQNFTGKVVEVVSGDCLVVA
SQ  DDSIPFGSPMAERRVCLSSIRSPKMGNPRREEKPAPYAREAKEFLRQKLIGMEVIVQMEYSRKISPGDGVTTSGAGDRVM
SQ  DFGSVFLPSPTKGDTAVAAAATPGANIAELIISRGLGTVVRHRDFEERSNHYDALLAAEARAIAGKKNIHSAKDSPALHI
SQ  ADLTVASAKKAKDFLPSLQRINQISAVVEYVLSGHRFKLYIPKESCSIAFAFSGVRCPGRGEPYSEEAIALMRRKIMQRD
SQ  VEIVVENVDRTGTFLGSMWEKNSKTNAGTYLLEAGLAKMQTGFGADRIPEAHILEMAERSAKNQKLKIWENYVEGEEVVN
SQ  GSSKVETRQKETLKVVVTEVLGGGRFYVQTVGDQKVASIQNQLAALSLKDAPIIGSFNPKKGDIVLAQFSLDNSWNRAMI
SQ  VNGPRGAVQSPEEEFEVFYIDYGNQEIVPYSAIRPVDPSVSSAPGLAQLCRLAYIKVPGKEEDFGRDAGEYLHTVTLESG
SQ  KEFRAVVEERDTSGGKVKGQGTGTELVVTLIAVDDEISVNAAMLQEGIARMEKRRRWEPKDKQAALDALEKFQDEARKSR
SQ  TGIWEYGDIQSDDEDNVPVRKPGRG
//