ID  Q9GUI6;
PN  Protein pid-5;
GN  pid;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:33231880}. Cytoplasm, P-body {ECO:0000269|PubMed:33231880}. Note=Co-localizes with pid-4 at P granules in germ cells. {ECO:0000269|PubMed:33231880}.
DR  UNIPROT: Q9GUI6;
DR  UNIPROT: A0A163VU95;
DR  UNIPROT: A0A168HAZ2;
DR  Pfam: PF01321;
DR  Pfam: PF00557;
DR  Pfam: PF16188;
DE  Function: Together with pid-4, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-4, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-4, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-4, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880). {ECO:0000269|PubMed:33231880}.
DE  Reference Proteome: Yes;
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0070006;
GO  GO:0031047;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPTSADDSLPLEDSEECDAYIAKFLRPRTHLFSTVKQEKQRRESHDNKYETAVRSKAIMPSQASKVYRKEMFYSTSKCDS
SQ  RFINNLHTFNTFDGGSGYSEASPHYAMDFVKNKGFADDEMAGHLKSLEVSRKMTENVKWLNDNRNDLKTALRRSNSCPEF
SQ  PIDRDREKITTLRRNEKRNENAKISNFDASFVPELCCSDDYPSILCSIATAFKTVVSRVNAQSIGSGELKIAKVLCSTED
SQ  LFAYVIPKRFNTRDALFAFSNQFRAWLEYKPNVQLYTHYRFINVILYLEEFKHERTEFRRARHVCNLKSRRNHGLFLELD
SQ  TGMLRVVEITPEKVRFLANSWAHNPSAIVEVRFDGVKNEKDISEEIQAIRNTGRATMISFDREHREHMNGKWPNPRTWSS
SQ  LGTVVLRRECTHHKDHSKPPLTRLFCEDRDCIGLCSTGDYFKVPIPEEPNPSHDKLVELRARFASERTLGYTDRTPIAAY
SQ  ILPNTDAHQNELIPDFFSRVQFLNGYSGPSGLAIITLNEAMFWVDNGLLKSAESQVDDRSWTVKEYQSVEEVINWLAKIL
SQ  PPKSKVGFDPTLVSYTWHQQALQSMTSDRFELVAIPGNIVDEIWRMRPFQRGDVVKMLDKNTPEIPVHVKIDRLRKSLKP
SQ  NKCLAAVITSLEDIMWLLNIRGNDLPYNPVTYSYLFITMSDVRLFIDAKRLNDVSKAYFARQSIDVDDYKAASPYIYDWI
SQ  SATKSSFADKKILISPETNYLIGRLIGEDHSMIDPSIMERIKKIKNTDQLKGMRASNLRDSIAIVEFLCKFEKERRDGYT
SQ  FTEYELAADIEEVKTRNREYIGLKQPTIFSAGEHSSVHAHRPDAQKIVFHYQQFMFQTGSHYTDGATNCARTIWDSYPTE
SQ  EFMNQYTLVLKGHIRLASASFPKTLTYGSRLDIFARIALWDAGLDYDHETGHSVGHFLNIRDTQIVIGREPYSSNSIIEA
SQ  GQVMTIEPGYYSEGMYGIRIGNCYETVDVTLSQNDQYFLRFEPLTLIPIQTSIVNKDLLTSEEINWLNKYHFKVFSKIGY
SQ  ILRKENRMEEYDWLFNACQPI
//