ID  Q9H0R5;
PN  Guanylate-binding protein 3;
GN  GBP3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
DR  UNIPROT: Q9H0R5;
DR  UNIPROT: A2A317;
DR  UNIPROT: A6NF86;
DR  UNIPROT: B2RTW0;
DR  UNIPROT: F8UW81;
DR  UNIPROT: Q05D54;
DR  UNIPROT: Q5T8L8;
DR  UNIPROT: Q5T8L9;
DR  UNIPROT: Q6P3V3;
DR  UNIPROT: Q9NV33;
DR  Pfam: PF02263;
DR  Pfam: PF02841;
DR  PROSITE: PS51715;
DR  OMIM: 600413;
DR  DisGeNET: 2635;
DE  Function: Exhibits antiviral activity against influenza virus. {ECO:0000269|PubMed:22106366}.
DE  Reference Proteome: Yes;
DE  Interaction: P32456; IntAct: EBI-21835834; Score: 0.63
DE  Interaction: O95819; IntAct: EBI-8547663; Score: 0.59
DE  Interaction: Q5NF74; IntAct: EBI-2798928; Score: 0.00
DE  Interaction: P32455; IntAct: EBI-21864916; Score: 0.63
DE  Interaction: P60903; IntAct: EBI-20909232; Score: 0.40
DE  Interaction: P16403; IntAct: EBI-20912036; Score: 0.40
DE  Interaction: Q9H0R5; IntAct: EBI-26472578; Score: 0.51
DE  Interaction: Q96PP8; IntAct: EBI-26472594; Score: 0.51
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0000139;
GO  GO:0048471;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0042802;
GO  GO:0042803;
GO  GO:0071346;
GO  GO:0071347;
GO  GO:0071356;
GO  GO:0051607;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWM
SQ  WCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDE
SQ  NENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI
SQ  HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQI
SQ  ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEA
SQ  SSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL
SQ  TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLK
SQ  ERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
//