ID  Q9H4L5;
PN  Oxysterol-binding protein-related protein 3;
GN  OSBPL3;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000269|PubMed:16143324}. Cytoplasm, cytosol {ECO:0000269|PubMed:16143324}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}; Peripheral membrane protein {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. Cell projection, filopodium tip {ECO:0000269|PubMed:18270267}. Nucleus membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9DBS9}.
DR  UNIPROT: Q9H4L5;
DR  UNIPROT: A4D167;
DR  UNIPROT: A4D168;
DR  UNIPROT: A4D169;
DR  UNIPROT: A4D170;
DR  UNIPROT: A4D171;
DR  UNIPROT: A4D172;
DR  UNIPROT: B8ZZ79;
DR  UNIPROT: B8ZZP0;
DR  UNIPROT: O14591;
DR  UNIPROT: O43357;
DR  UNIPROT: O43358;
DR  UNIPROT: Q8N702;
DR  UNIPROT: Q8N703;
DR  UNIPROT: Q8N704;
DR  UNIPROT: Q8NFH0;
DR  UNIPROT: Q8NFH1;
DR  UNIPROT: Q8NI12;
DR  UNIPROT: Q8NI13;
DR  UNIPROT: Q9BZF4;
DR  UNIPROT: Q9UED6;
DR  PDB: 7CYZ;
DR  PDB: 7DEI;
DR  PDB: 7DEJ;
DR  Pfam: PF01237;
DR  Pfam: PF15409;
DR  PROSITE: PS01013;
DR  PROSITE: PS50003;
DR  OMIM: 606732;
DR  DisGeNET: 26031;
DE  Function: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
DE  Reference Proteome: Yes;
DE  Interaction: P61981; IntAct: EBI-7303529; Score: 0.69
DE  Interaction: P31946; IntAct: EBI-7305790; Score: 0.59
DE  Interaction: P31947; IntAct: EBI-7544306; Score: 0.40
DE  Interaction: Q04917; IntAct: EBI-1644092; Score: 0.53
DE  Interaction: P03366; IntAct: EBI-6174791; Score: 0.46
DE  Interaction: Q9Q2G4; IntAct: EBI-6174875; Score: 0.56
DE  Interaction: O95292; IntAct: EBI-8801774; Score: 0.35
DE  Interaction: Q9H6Z9; IntAct: EBI-12503146; Score: 0.35
DE  Interaction: Q6ZWV7; IntAct: EBI-10997876; Score: 0.35
DE  Interaction: Q14683; IntAct: EBI-11040305; Score: 0.35
DE  Interaction: F8VQC7; IntAct: EBI-11104527; Score: 0.35
DE  Interaction: Q9R0Q3; IntAct: EBI-11111571; Score: 0.35
DE  Interaction: Q9P0L0; IntAct: EBI-11120309; Score: 0.35
DE  Interaction: P09450; IntAct: EBI-11127973; Score: 0.35
DE  Interaction: Q8N4V1; IntAct: EBI-11130635; Score: 0.35
DE  Interaction: Q15560; IntAct: EBI-24293360; Score: 0.56
DE  Interaction: Q8N8B7; IntAct: EBI-24300464; Score: 0.56
DE  Interaction: Q9Y2P0; IntAct: EBI-24306429; Score: 0.56
DE  Interaction: Q5T619; IntAct: EBI-24314910; Score: 0.56
DE  Interaction: O00444; IntAct: EBI-24327550; Score: 0.56
DE  Interaction: Q3B820; IntAct: EBI-24328349; Score: 0.56
DE  Interaction: Q96EZ8; IntAct: EBI-24331233; Score: 0.56
DE  Interaction: P60520; IntAct: EBI-24342952; Score: 0.56
DE  Interaction: P19544; IntAct: EBI-24350451; Score: 0.56
DE  Interaction: O43395; IntAct: EBI-24351483; Score: 0.56
DE  Interaction: Q08AH1; IntAct: EBI-24352702; Score: 0.56
DE  Interaction: Q9H0R8; IntAct: EBI-24363322; Score: 0.56
DE  Interaction: Q86X27; IntAct: EBI-25244819; Score: 0.56
DE  Interaction: P62913; IntAct: EBI-25248804; Score: 0.56
DE  Interaction: Q8TDR2; IntAct: EBI-24364594; Score: 0.56
DE  Interaction: Q9Y228; IntAct: EBI-24506787; Score: 0.56
DE  Interaction: Q05516; IntAct: EBI-24369800; Score: 0.56
DE  Interaction: Q6ZNH5; IntAct: EBI-24370723; Score: 0.56
DE  Interaction: Q99633; IntAct: EBI-24372266; Score: 0.56
DE  Interaction: Q96MX3; IntAct: EBI-24395759; Score: 0.56
DE  Interaction: Q8TBB1; IntAct: EBI-24425275; Score: 0.56
DE  Interaction: Q96C24; IntAct: EBI-24450153; Score: 0.56
DE  Interaction: Q13895; IntAct: EBI-24452794; Score: 0.56
DE  Interaction: Q9Y3M2; IntAct: EBI-11941222; Score: 0.00
DE  Interaction: Q9Y597; IntAct: EBI-11942327; Score: 0.00
DE  Interaction: Q76RG8; IntAct: EBI-14063537; Score: 0.35
DE  Interaction: Q96JJ6; IntAct: EBI-21570881; Score: 0.35
DE  Interaction: Q9NWT6; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: O14965; IntAct: EBI-21639587; Score: 0.35
DE  Interaction: Q96FN4; IntAct: EBI-21659658; Score: 0.35
DE  Interaction: Q9P1U1; IntAct: EBI-21724091; Score: 0.35
DE  Interaction: Q9NZM5; IntAct: EBI-21744295; Score: 0.35
DE  Interaction: O43900; IntAct: EBI-21747441; Score: 0.35
DE  Interaction: O95159; IntAct: EBI-21768155; Score: 0.35
DE  Interaction: Q8N5I2; IntAct: EBI-21770417; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-21787335; Score: 0.35
DE  Interaction: Q13077; IntAct: EBI-21795913; Score: 0.35
DE  Interaction: Q9H0U9; IntAct: EBI-21872538; Score: 0.35
DE  Interaction: A1L0T0; IntAct: EBI-21879063; Score: 0.35
DE  Interaction: Q6NXR4; IntAct: EBI-21899961; Score: 0.40
DE  Interaction: P27348; IntAct: EBI-21902679; Score: 0.35
DE  Interaction: P63104; IntAct: EBI-21909838; Score: 0.35
DE  Interaction: Q9UHD2; IntAct: EBI-20200875; Score: 0.35
DE  Interaction: Q9H492; IntAct: EBI-30830128; Score: 0.44
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0032433;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0097038;
GO  GO:0005886;
GO  GO:0015485;
GO  GO:0032934;
GO  GO:0015248;
GO  GO:0006699;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGI
SQ  LKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVN
SQ  HFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLL
SQ  QSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYS
SQ  DGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRR
SQ  IHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISD
SQ  NLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLC
SQ  EELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHA
SQ  ESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKV
SQ  NFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSK
SQ  SLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSK
SQ  LDHPVLW
//