ID  Q9H7Z7;
PN  Prostaglandin E synthase 2 truncated form;
GN  PTGES2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000255}. [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12835322}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269|PubMed:12835322}.
DR  UNIPROT: Q9H7Z7;
DR  UNIPROT: Q53EW9;
DR  UNIPROT: Q5SYV6;
DR  UNIPROT: Q96GI0;
DR  UNIPROT: Q96GL2;
DR  Pfam: PF13417;
DR  PROSITE: PS00195;
DR  PROSITE: PS51354;
DR  PROSITE: PS50405;
DR  OMIM: 608152;
DR  DisGeNET: 80142;
DE  Function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH- dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}.
DE  Reference Proteome: Yes;
DE  Interaction: K9N7C7; IntAct: EBI-26374966; Score: 0.35
DE  Interaction: P0C6X7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-25491011; Score: 0.53
DE  Interaction: Q01780; IntAct: EBI-373752; Score: 0.00
DE  Interaction: P01106; IntAct: EBI-1237540; Score: 0.35
DE  Interaction: P16104; IntAct: EBI-2564373; Score: 0.35
DE  Interaction: Q5NFN4; IntAct: EBI-2803788; Score: 0.00
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: P42858; IntAct: EBI-6452059; Score: 0.40
DE  Interaction: Q5VU69; IntAct: EBI-10308949; Score: 0.56
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: Q13296; IntAct: EBI-21513670; Score: 0.35
DE  Interaction: P61421; IntAct: EBI-21518921; Score: 0.35
DE  Interaction: P80370; IntAct: EBI-21555448; Score: 0.35
DE  Interaction: Q07954; IntAct: EBI-21684279; Score: 0.35
DE  Interaction: O14949; IntAct: EBI-21689809; Score: 0.35
DE  Interaction: O60518; IntAct: EBI-21713634; Score: 0.35
DE  Interaction: Q9UG63; IntAct: EBI-21764870; Score: 0.35
DE  Interaction: Q8N140; IntAct: EBI-21773860; Score: 0.35
DE  Interaction: E9PK12; IntAct: EBI-21841096; Score: 0.35
DE  Interaction: Q0VDI3; IntAct: EBI-21891210; Score: 0.35
DE  Interaction: Q6UWI4; IntAct: EBI-21898440; Score: 0.35
DE  Interaction: O75208; IntAct: EBI-21930142; Score: 0.35
DE  Interaction: O00483; IntAct: EBI-21930681; Score: 0.35
DE  Interaction: Q9C002; IntAct: EBI-21935327; Score: 0.35
DE  Interaction: P07550; IntAct: EBI-20801899; Score: 0.37
DE  Interaction: A0A0H3LG06; IntAct: EBI-25401076; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
GO  GO:0035578;
GO  GO:0005829;
GO  GO:0005576;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0005739;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0036134;
GO  GO:0003677;
GO  GO:0043295;
GO  GO:0020037;
GO  GO:0016829;
GO  GO:0050220;
GO  GO:0019371;
GO  GO:0006629;
GO  GO:0045893;
GO  GO:0046903;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHL
SQ  RAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQ
SQ  QLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
SQ  WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGK
SQ  DRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
//