ID  Q9HCI5;
PN  Melanoma-associated antigen E1;
GN  MAGEE1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9HCI5;
DR  UNIPROT: Q5JXC7;
DR  UNIPROT: Q86TG0;
DR  UNIPROT: Q8TD92;
DR  UNIPROT: Q9H216;
DR  Pfam: PF01454;
DR  PROSITE: PS50838;
DR  OMIM: 300759;
DR  DisGeNET: 57692;
DE  Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.
DE  Reference Proteome: Yes;
DE  Interaction: Q93009; IntAct: EBI-30844403; Score: 0.59
DE  Interaction: Q8ZAW9; IntAct: EBI-2865026; Score: 0.00
DE  Interaction: Q13263; IntAct: EBI-5651510; Score: 0.52
DE  Interaction: Q96D98; IntAct: EBI-24354283; Score: 0.68
DE  Interaction: P23508; IntAct: EBI-24430902; Score: 0.56
DE  Interaction: Q96RY5; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q9ULH0; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q9H6U6; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q9BSU1; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q8WXI9; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q8N6I1; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: Q2TBE0; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: P49750; IntAct: EBI-21858269; Score: 0.35
DE  Interaction: P20936; IntAct: EBI-25373525; Score: 0.35
DE  Interaction: P30086; IntAct: EBI-25381702; Score: 0.35
GO  GO:0030425;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0045211;
GO  GO:0000122;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFV
SQ  PPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVP
SQ  STSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATEGLSTSVQATPDEGPSTSVPPTA
SQ  TEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQSISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSV
SQ  PPTPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGP
SQ  GSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSR
SQ  VAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYIL
SQ  LNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDY
SQ  RPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAE
SQ  VPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGT
SQ  ELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLS
SQ  QRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR
//