ID  Q9JIB0;
PN  Ran guanine nucleotide release factor;
GN  Rangrf;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:11733047}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9HD47}. Cytoplasm {ECO:0000269|PubMed:18184654}. Cell membrane {ECO:0000250|UniProtKB:Q9HD47}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HD47}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9HD47}. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000269|PubMed:11733047}.
DR  UNIPROT: Q9JIB0;
DR  UNIPROT: Q9CWZ0;
DR  Pfam: PF04603;
DE  Function: May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830). {ECO:0000250|UniProtKB:Q9HD47, ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:11733047, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:23420830}.
DE  Reference Proteome: Yes;
DE  Interaction: Q61820; IntAct: EBI-310252; Score: 0.37
DE  Interaction: Q9Z0S9; IntAct: EBI-20974786; Score: 0.37
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0014704;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005791;
GO  GO:0005085;
GO  GO:0031267;
GO  GO:0017080;
GO  GO:0044325;
GO  GO:0006888;
GO  GO:0060047;
GO  GO:0006913;
GO  GO:2000010;
GO  GO:1903078;
GO  GO:0032527;
GO  GO:0006606;
GO  GO:0098905;
GO  GO:0098909;
GO  GO:0003254;
GO  GO:1900825;
GO  GO:0042391;
GO  GO:0090226;
GO  GO:1902305;
GO  GO:2000649;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q9HD47};
SQ  MEPNRNCPLFGGAFSAILPTGAIDVSDLRPVPDNQEVFCHPVTDQSLIIELLELQAHVQGEAAARYHFEDVGRVQGARAV
SQ  HVLSVQPLCLENLSLRGCCQDAWSLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRSLGPENLSCP
SQ  PWSLSNFEQLVTSLTLHDPNLFGPQ
//