ID  Q9JJV9;
PN  Sodium channel protein type 5 subunit alpha;
GN  Scn5a;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:11834499, ECO:0000269|PubMed:23420830}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q14524}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P15389}. Note=RANGRF promotes trafficking to the cell membrane. {ECO:0000269|PubMed:23420830}.
DR  UNIPROT: Q9JJV9;
DR  UNIPROT: E9Q1D2;
DR  UNIPROT: Q3UH91;
DR  Pfam: PF00520;
DR  Pfam: PF06512;
DR  Pfam: PF11933;
DE  Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity). {ECO:0000250|UniProtKB:Q14524, ECO:0000269|PubMed:11834499, ECO:0000269|PubMed:23420830}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9Z0J4; IntAct: EBI-15712165; Score: 0.35
DE  Interaction: Q6Q477; IntAct: EBI-15712165; Score: 0.35
DE  Interaction: Q61234; IntAct: EBI-15712165; Score: 0.35
DE  Interaction: Q4U4S6; IntAct: EBI-26520955; Score: 0.40
GO  GO:0005901;
GO  GO:0009986;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0014704;
GO  GO:0016328;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0042383;
GO  GO:0034706;
GO  GO:0030315;
GO  GO:0001518;
GO  GO:0030018;
GO  GO:0030506;
GO  GO:0005516;
GO  GO:0019899;
GO  GO:0017134;
GO  GO:0050998;
GO  GO:0019904;
GO  GO:0019901;
GO  GO:0097110;
GO  GO:0044325;
GO  GO:0031625;
GO  GO:0005244;
GO  GO:0005248;
GO  GO:0086060;
GO  GO:0086061;
GO  GO:0086006;
GO  GO:0086062;
GO  GO:0086063;
GO  GO:0086014;
GO  GO:0086016;
GO  GO:0086067;
GO  GO:0086043;
GO  GO:0086002;
GO  GO:0060048;
GO  GO:0003231;
GO  GO:0071277;
GO  GO:0051899;
GO  GO:0086010;
GO  GO:0098912;
GO  GO:0086045;
GO  GO:0086048;
GO  GO:0086012;
GO  GO:0086047;
GO  GO:0086046;
GO  GO:0019228;
GO  GO:0045760;
GO  GO:0050679;
GO  GO:0010460;
GO  GO:0010765;
GO  GO:0060371;
GO  GO:0060372;
GO  GO:0086004;
GO  GO:0002027;
GO  GO:0086091;
GO  GO:1902305;
GO  GO:0060373;
GO  GO:0060307;
GO  GO:0014894;
GO  GO:0014070;
GO  GO:0086015;
GO  GO:0098719;
GO  GO:0035725;
GO  GO:0006814;
GO  GO:0086005;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:D0E0C2};
SQ  MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSATSQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPRELIGEPL
SQ  EDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYV
SQ  EYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
SQ  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGT
SQ  TDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLG
SQ  SFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERRSKRRK
SQ  RLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTS
SQ  LLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGP
SQ  QMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFAD
SQ  LTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSR
SQ  MGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPR
SQ  WHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNN
SQ  LQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGT
SQ  PGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQESQVVSGGHEPPQEPRAWSQVSETTSSEAEASTSQADWQQE
SQ  REAEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTC
SQ  YRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI
SQ  VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG
SQ  KFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP
SQ  QWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ
SQ  GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVV
SQ  VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN
SQ  FAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIII
SQ  SFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINM
SQ  DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQ
SQ  RSVKHASFLFRQQAGSSGLSDEDAPEREGLIAYMMNENFSRRSGPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSR
SQ  SEDLADFPPSPDRDRESIV
//