ID  Q9JKC9;
PN  Synergin gamma;
GN  Synrg;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:10477754}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10477754}; Peripheral membrane protein {ECO:0000269|PubMed:10477754}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UMZ2}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9UMZ2}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin (By similarity). Associates with membranes via the adapter protein complex AP-1 (PubMed:10477754). Colocalizes with AP1G1 (PubMed:10477754). {ECO:0000250|UniProtKB:Q9UMZ2, ECO:0000269|PubMed:10477754}.
DR  UNIPROT: Q9JKC9;
DR  UNIPROT: A1EC70;
DR  UNIPROT: A1EC72;
DR  UNIPROT: A1EC74;
DR  UNIPROT: A1EC75;
DR  UNIPROT: Q9R145;
DR  PROSITE: PS50031;
DE  Function: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP- 1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). {ECO:0000250|UniProtKB:Q9UMZ2}.
DE  Reference Proteome: Yes;
GO  GO:0030130;
GO  GO:0048471;
GO  GO:0006897;
GO  GO:0015031;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:10477754};
SQ  MALRPGAGASGAAGAGTGPGGAGSFMFPVAGGMRPPQGLIPMQQQGFPMVSVMQPNMQGMMGMNYSSQMSQGPIAMQAGI
SQ  PMGPMPAAGVPFLGQPPFLGMRPAAPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEK
SQ  NRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPDCPTSSHSTKTVSPSSAFLGEDEFSGFMQGPVELPTCGPSSTAQPFQ
SQ  SFLPSTPLGQLHTQKAGAQPLPPGQAPVSFAVHGVHGQIPCLSAASASHSMQKAGPSLEEKLLVSCDISASGQEHIKLSS
SQ  PEAGHRAVVPGSSKNSPGLMAHNGGAVDGCVSGPTTAVAEKTSDQNLSKEESGVGVFPSQDPVQPRMPPWIYNESLVPDA
SQ  YKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMVAVTQRGVPAMSPDTLNQFPA
SQ  APIPTLSGFPMTLPTPVSQPTAMTSGPAGSIPLSLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGKTEEDDFQDFQ
SQ  DASKSGSIDDSFTDFQEVPASSKTSNSQHGNSAPSLLIPLPGTKASTDKYAVFKGISAEKPSENPASFGESGDKYSAFRE
SQ  LEPTADSKPLGESFAEFRSTGTDDGFTDFKTADSVSPLEPPTKDSFPSAFASGAAQQTQTQVKTPLNLADLDMFSSVDCS
SQ  GEKPVPFSAAFSTSKSVSSRPQPAGSAAAPASLASTKASSLADDFGEFNLFGEYSNPASVGEQDDFADFMAFGNSSIPSE
SQ  PKADDKYEALREEGSPGALSTSTVEGAHNPPVSSSKYDVFKQLSLEGAGLAIEEFKENTPSTKSDGDFADFHSSKFSSTS
SQ  SDKSLGEKAVAFRHAKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPA
SQ  AGSALASEDALPETPFPAFASFKDMMPQTTEQKEYESGDFQDFTRQDMPMVDRSQENTCPSPASSVASHETPKEGADDFG
SQ  EFQSEKPKISKFDFLVANSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLSERA
SQ  ALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALDVIKKANDTLNGISSSAVCTEVIQSAQGMEYLLGVVEVYRVTKRVE
SQ  LGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLTTLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEETPA
SQ  EEQPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLLLPDLL
//