ID  Q9JKY5;
PN  Huntingtin-interacting protein 1-related protein;
GN  Hip1r;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
DR  UNIPROT: Q9JKY5;
DR  UNIPROT: Q3UJ14;
DR  Pfam: PF07651;
DR  Pfam: PF16515;
DR  Pfam: PF01608;
DR  PROSITE: PS50942;
DR  PROSITE: PS50945;
DE  Function: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
DE  Reference Proteome: Yes;
DE  Interaction: Q01279; IntAct: EBI-27088765; Score: 0.40
DE  Interaction: P04973; IntAct: EBI-7374625; Score: 0.37
DE  Interaction: P04975; IntAct: EBI-7374604; Score: 0.57
DE  Interaction: Q61210; IntAct: EBI-649779; Score: 0.37
DE  Interaction: Q60598; IntAct: EBI-7285203; Score: 0.49
DE  Interaction: Q96B97; IntAct: EBI-7167363; Score: 0.40
DE  Interaction: G3V6K6; IntAct: EBI-27088754; Score: 0.52
GO  GO:0016324;
GO  GO:0005938;
GO  GO:0005905;
GO  GO:0030136;
GO  GO:0030665;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0032839;
GO  GO:0043197;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0005739;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0032587;
GO  GO:0097060;
GO  GO:0003779;
GO  GO:0051015;
GO  GO:0035615;
GO  GO:0030276;
GO  GO:0032051;
GO  GO:0042802;
GO  GO:0035091;
GO  GO:0005547;
GO  GO:0043325;
GO  GO:0080025;
GO  GO:0005546;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0017124;
GO  GO:0007015;
GO  GO:0006919;
GO  GO:0006915;
GO  GO:0048268;
GO  GO:0055123;
GO  GO:0006897;
GO  GO:0061024;
GO  GO:0030837;
GO  GO:0043066;
GO  GO:0034316;
GO  GO:0043065;
GO  GO:1905445;
GO  GO:2000370;
GO  GO:0045742;
GO  GO:1901030;
GO  GO:2000588;
GO  GO:0032092;
GO  GO:0050821;
GO  GO:0006898;
GO  GO:0032956;
GO  GO:2000369;
GO  GO:0030100;
GO  GO:0060453;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLSSSS
SQ  ILSWKFCHVLHKVLRDGHPNVLHDYQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEV
SQ  LEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSC
SQ  LPADTLQGHRDRFHEQFHSLKNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIE
SQ  ISSAPPAGEPVVVADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNGLEAELEEQRK
SQ  QKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKLKEKHSELINTHAELLRKNADTAKQLTVTQQ
SQ  SQEEVARVKEQLAFQMEQAKRESEMKMEEQSDQLEKLKRELAARAGELARAQEALSRTEQSGSELSSRLDTLNAEKEALS
SQ  GVVRQREAELLAAQSLVREKEEALSQEQQRSSQEKGELRGQLAEKESQEQGLRQKLLDEQLAVLRSAAAEAEAILQDAVS
SQ  KLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEQGHTQYLASSEDASALVAALTRFSHLAADTIVNGAATSHLAPTDPADR
SQ  LMDTCRECGARALELVGQLQDQTVLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDAVRR
SQ  IEDMMSQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG
SQ  WGATQLVESADKVVLHMGKYEELIVCSHEIAASTAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQI
SQ  EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEEEPSRPSPAPRSGATKKPPL
SQ  AQKPSIAPRTDNQLDKKDGVYPAQLVNY
//