ID  Q9M077;
PN  Serine/threonine-protein kinase Aurora-1;
GN  AUR1;
OS  3702;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, phragmoplast. Note=Nuclear membrane in interphase cells, spindle poles at prophase, mitotic spindle from metaphase to telophase and equatorial cell plate at telophase.
DR  UNIPROT: Q9M077;
DR  UNIPROT: Q8LBX4;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Phosphorylates specifically 'Ser-10' of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Colocalizes also with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward 'Ser-28' of histone H3. {ECO:0000269|PubMed:15722465, ECO:0000269|PubMed:16028112, ECO:0000269|PubMed:22150830}.
DE  Reference Proteome: Yes;
GO  GO:0009504;
GO  GO:0032133;
GO  GO:0005874;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005634;
GO  GO:0009524;
GO  GO:0005819;
GO  GO:0005876;
GO  GO:0051233;
GO  GO:0000922;
GO  GO:0005524;
GO  GO:0035175;
GO  GO:0035174;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0051301;
GO  GO:0007052;
GO  GO:0006468;
GO  GO:0032465;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAIPTETQHQEKEASDASAAAAQKRWTLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQVEHQLRREV
SQ  EIQSHLRHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENL
SQ  LIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAMEHSDTYRRIVQ
SQ  VDLKFPPKPIISASAKDLISQMLVKESSQRLPLHKLLEHPWIVQNADPSGIYRV
//