ID  Q9N0A4;
PN  Prostaglandin E synthase 2 truncated form;
GN  PTGES2;
OS  9541;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}. [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H7Z7}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000250|UniProtKB:Q9H7Z7}.
DR  UNIPROT: Q9N0A4;
DR  UNIPROT: Q5DI73;
DR  PDB: 1Z9H;
DR  PDB: 2PBJ;
DR  Pfam: PF13417;
DR  PROSITE: PS00195;
DR  PROSITE: PS51354;
DR  PROSITE: PS50405;
DE  Function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:11866447, PubMed:23426368). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:23426368). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:23426368). {ECO:0000269|PubMed:11866447, ECO:0000269|PubMed:23426368}.
DE  Reference Proteome: Yes;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0036134;
GO  GO:0043295;
GO  GO:0020037;
GO  GO:0042802;
GO  GO:0016829;
GO  GO:0050220;
GO  GO:0001516;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAPATRVVRALWTGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGQGPVAAARKGSPRLLGAAALALGGALGLYHTARWHL
SQ  HAQDLHAERSAVQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVLRAEIKFSSYRKVPILVAQEGESSQ
SQ  QLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNDQGKEVTEFGNKYWLMLNEKEAQQVYSGKEARTEEMKWRQWADD
SQ  WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGK
SQ  DRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
//