ID  Q9N0Z4;
PN  Phospholipid-transporting ATPase IF;
GN  ATP11B;
OS  9986;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Recycling endosome membrane {ECO:0000250|UniProtKB:Q9Y2G3}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:Q9Y2G3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y2G3}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9Y2G3}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes. {ECO:0000250|UniProtKB:Q9Y2G3}. [Isoform 2]: Nucleus inner membrane {ECO:0000269|PubMed:11058586}; Multi-pass membrane protein {ECO:0000255}.
DR  UNIPROT: Q9N0Z4;
DR  UNIPROT: Q8WMR2;
DR  Pfam: PF16212;
DR  Pfam: PF16209;
DR  PROSITE: PS00154;
DE  Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes. May contribute to the maintenance of membrane lipid asymmetry in endosome compartment. {ECO:0000250|UniProtKB:Q9Y2G3}. [Isoform 2]: Appears to play a role in the subnuclear trafficking of transcription factors with RING motifs. {ECO:0000269|PubMed:11058586, ECO:0000269|PubMed:18584949}.
DE  Reference Proteome: Yes;
GO  GO:0005769;
GO  GO:0005783;
GO  GO:0005794;
GO  GO:0016021;
GO  GO:0005637;
GO  GO:0055038;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0000287;
GO  GO:0090555;
GO  GO:0090556;
GO  GO:0015917;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  LGFDPPHQSDTRTIYIANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPI
SQ  TSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDG
SQ  SCHVTTASLDGETNLKTHVAVPETAVLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGAR
SQ  LKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLIILISEAIISTILKYTWQAEEKWDEPWYNQKTEH
SQ  QRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDK
SQ  TGTLTENEMQFRECSIHGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHVNSLSHLTSSSSFRTSPENDTELIKEHDLF
SQ  FKAVSLCHTVQISSVQTDGIGDGPWQSSLAPSQLEYYASSPDEKALVEAAARIGIVFVGNTEETMEVKILGKLERYKLLH
SQ  VLEFDSDRRRMSVIVQAPSGERFLFAKGAESSILPKCIGGEIEKTRIHVDEFALKGLRTLCVAYRQFTSKEYEVIDRRLF
SQ  EARTALQQREEKLADVFHYIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMN
SQ  ILELTNQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIK
SQ  ISPEKPITIGCWDGANDVSMIQEAHVGIGIMGKERRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVC
SQ  FITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHIDPHILQNKPTLYRDISKNRLLSIKTFLYWTILG
SQ  FSRSFIFLFGSYFLIGKDASLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGG
SQ  ILWPFLGSQNMYFVFIQLVSSGSAWFAIILMVVTCLFLDVMKKVFDRQLHPTSTEKAQLTETNSSIKCVDSLCCFPEGET
SQ  TCTSVRRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
//