ID  Q9N261;
PN  Leupaxin;
GN  LPXN;
OS  9986;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9N261;
DR  UNIPROT: G1TMN6;
DR  Pfam: PF00412;
DR  PROSITE: PS00478;
DR  PROSITE: PS50023;
DE  Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0042995;
GO  GO:0005925;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0002102;
GO  GO:0046872;
GO  GO:0007155;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEELDALLEELERSTLQDSDEYSNSAPLPLDQSSRKESNLDETSKMLSVQDSTNPFPVQLVYTTNIQDRNVYSEVQEPKK
SQ  SPPPAKTSAAAQLDELMAHLSEMQAKVSVKADAGKKPVSENLDHKASLDSMLGGLEQELQNLGIPTVPKGHCASCQKPIV
SQ  GKVIHALGQSWHPEHFICTHCKEEIGSSPFFERSGLAYCPKDYHHLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHC
SQ  GEVFGTEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSTGSFFELEGRPFCELH
SQ  YHQRRGTLCHGCGQPITGRCISAMGHKFHPEHFVCAFCLTQLSKGVFREQNDKTYCQPCFNKLFSL
//