ID  Q9NDC9;
PN  Lissencephaly-1 homolog;
GN  lis;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP- Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Chromosome, centromere, kinetochore {ECO:0000305}. Nucleus envelope {ECO:0000305|PubMed:20005871}. Note=Localizes to the plus end of microtubules (By similarity). Concentrates in the vicinity of microtubule asters, kinetochores, the cell cortex and the perinuclear region (PubMed:15331665). Probably recruited to the nuclear envelope by unc-83 (PubMed:20005871). {ECO:0000250|UniProtKB:P63004, ECO:0000269|PubMed:15331665, ECO:0000305|PubMed:20005871}.
DR  UNIPROT: Q9NDC9;
DR  UNIPROT: O45742;
DR  Pfam: PF08513;
DR  Pfam: PF00400;
DR  PROSITE: PS50896;
DR  PROSITE: PS00678;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division (PubMed:11685578, PubMed:15331665). Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). Required for neuronal cell differentiation (PubMed:15254012). {ECO:0000255|HAMAP-Rule:MF_03141, ECO:0000269|PubMed:11685578, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:15331665, ECO:0000269|PubMed:16996038, ECO:0000269|PubMed:20005871}.
DE  Reference Proteome: Yes;
DE  Interaction: P13508; IntAct: EBI-6456381; Score: 0.37
DE  Interaction: P91001; IntAct: EBI-6460941; Score: 0.37
GO  GO:0005818;
GO  GO:1904115;
GO  GO:0005938;
GO  GO:0005737;
GO  GO:0005868;
GO  GO:0005881;
GO  GO:0000776;
GO  GO:0005874;
GO  GO:0005875;
GO  GO:0005815;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0005635;
GO  GO:0048471;
GO  GO:0045202;
GO  GO:0070840;
GO  GO:0051010;
GO  GO:0048854;
GO  GO:0051301;
GO  GO:0051026;
GO  GO:0009792;
GO  GO:0043652;
GO  GO:0000132;
GO  GO:0007281;
GO  GO:0040011;
GO  GO:0051661;
GO  GO:0031023;
GO  GO:0051012;
GO  GO:0007018;
GO  GO:0007100;
GO  GO:0007097;
GO  GO:0031022;
GO  GO:0048477;
GO  GO:0035046;
GO  GO:0008090;
GO  GO:0051225;
GO  GO:0051932;
GO  GO:0048489;
GO  GO:0047496;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHG
SQ  APTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAG
SQ  KQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIR
SQ  ISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPEGNSTHILFSGSRDRSIKAWNIN
SQ  TGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKV
SQ  WECR
//