ID  Q9NPB3;
PN  Calcium-binding protein 2;
GN  CABP2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19338761}. Cell membrane {ECO:0000269|PubMed:19338761}; Lipid-anchor {ECO:0000269|PubMed:19338761}; Cytoplasmic side {ECO:0000269|PubMed:19338761}. Golgi apparatus {ECO:0000269|PubMed:19338761}.
DR  UNIPROT: Q9NPB3;
DR  Pfam: PF00036;
DR  Pfam: PF13499;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DR  OMIM: 607314;
DR  OMIM: 614899;
DR  DisGeNET: 51475;
DE  Function: Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:Q9JLK4, ECO:0000269|PubMed:28183797}.
DE  Disease: Deafness, autosomal recessive, 93 (DFNB93) [MIM:614899]: A form of non-syndromic deafness characterized by stable, bilateral, symmetric, prelingual moderate to severe deafness. Hearing impairment is slightly more pronounced in the mid-frequencies, resulting in a distinctive shallow U-shaped audiogram. {ECO:0000269|PubMed:22981119, ECO:0000269|PubMed:28183797}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: Q7Z3Z2; IntAct: EBI-24796266; Score: 0.56
DE  Interaction: Q5JST6; IntAct: EBI-24280036; Score: 0.56
DE  Interaction: Q9H257; IntAct: EBI-24349898; Score: 0.56
DE  Interaction: A6NEM1; IntAct: EBI-24354781; Score: 0.56
DE  Interaction: Q96ED9; IntAct: EBI-24363653; Score: 0.56
DE  Interaction: P86480; IntAct: EBI-25247799; Score: 0.56
DE  Interaction: Q96M29; IntAct: EBI-25252219; Score: 0.56
DE  Interaction: Q9NPE3; IntAct: EBI-23679380; Score: 0.56
DE  Interaction: Q5T686; IntAct: EBI-23682258; Score: 0.56
DE  Interaction: Q9H1P6; IntAct: EBI-24667738; Score: 0.56
DE  Interaction: Q8IZF2; IntAct: EBI-23695711; Score: 0.56
DE  Interaction: Q9BRK3; IntAct: EBI-23698200; Score: 0.56
DE  Interaction: Q5JTJ3; IntAct: EBI-23706738; Score: 0.56
DE  Interaction: Q6NX45; IntAct: EBI-24681698; Score: 0.56
DE  Interaction: A8K8V0; IntAct: EBI-23728536; Score: 0.56
DE  Interaction: P52738; IntAct: EBI-23735866; Score: 0.56
DE  Interaction: O43623; IntAct: EBI-24705441; Score: 0.56
DE  Interaction: Q9BU61; IntAct: EBI-24705993; Score: 0.56
DE  Interaction: Q9BRJ7; IntAct: EBI-24717821; Score: 0.56
DE  Interaction: Q8NCR6; IntAct: EBI-24726274; Score: 0.56
DE  Interaction: Q8N6D5; IntAct: EBI-24738691; Score: 0.56
DE  Interaction: O00746; IntAct: EBI-23809170; Score: 0.56
DE  Interaction: P19237; IntAct: EBI-24741126; Score: 0.56
DE  Interaction: Q9UPQ4; IntAct: EBI-24765776; Score: 0.56
DE  Interaction: A0A0U1RQF7; IntAct: EBI-25278632; Score: 0.56
DE  Interaction: Q9H9P5; IntAct: EBI-24548110; Score: 0.56
DE  Interaction: Q8TBB0; IntAct: EBI-24654317; Score: 0.56
DE  Interaction: Q68EA5; IntAct: EBI-24654686; Score: 0.56
DE  Interaction: Q9H0A9; IntAct: EBI-24789004; Score: 0.56
DE  Interaction: Q6P5X5; IntAct: EBI-25202133; Score: 0.56
DE  Interaction: Q08117; IntAct: EBI-25267170; Score: 0.56
DE  Interaction: P35452; IntAct: EBI-25241483; Score: 0.56
DE  Interaction: Q8TAG6; IntAct: EBI-25275160; Score: 0.56
GO  GO:0005737;
GO  GO:0005794;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005246;
GO  GO:0005509;
GO  GO:1901385;
GO  GO:0007605;
GO  GO:0007165;
GO  GO:0007601;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:10625670};
SQ  MGNCAKRPWRRGPKDPLQWLGSPPRGSCPSPSSSPKEQGDPAPGVQGYSVLNSLVGPACIFLRPSIAATQLDRELRPEEI
SQ  EELQVAFQEFDRDRDGYIGCRELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDA
SQ  FREFDTNGDGRISVGELRAALKALLGERLSQREVDEILQDVDLNGDGLVDFEEFVRMMSR
//