ID  Q9NRZ7;
PN  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma;
GN  AGPAT3;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20537980, ECO:0000269|PubMed:21173190}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:21173190}.
DR  UNIPROT: Q9NRZ7;
DR  UNIPROT: D3DSL2;
DR  UNIPROT: Q3ZCU2;
DR  UNIPROT: Q6UWP6;
DR  UNIPROT: Q6ZUC6;
DR  UNIPROT: Q8N3Q7;
DR  UNIPROT: Q9NRZ6;
DR  Pfam: PF16076;
DR  Pfam: PF01553;
DR  OMIM: 614794;
DR  DisGeNET: 56894;
DE  Function: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). {ECO:0000250|UniProtKB:Q9D517, ECO:0000269|PubMed:21173190}.
DE  Reference Proteome: Yes;
DE  Interaction: A0PK00; IntAct: EBI-11898699; Score: 0.00
DE  Interaction: Q12982; IntAct: EBI-24609790; Score: 0.56
DE  Interaction: Q9BXJ8; IntAct: EBI-11930596; Score: 0.00
DE  Interaction: Q5NHZ4; IntAct: EBI-2803610; Score: 0.00
DE  Interaction: O43889; IntAct: EBI-8646574; Score: 0.37
DE  Interaction: Q6ZUT1; IntAct: EBI-24518926; Score: 0.56
DE  Interaction: Q00013; IntAct: EBI-24605803; Score: 0.56
DE  Interaction: Q96BA8; IntAct: EBI-24610867; Score: 0.56
DE  Interaction: Q14973; IntAct: EBI-24660485; Score: 0.56
DE  Interaction: Q13520; IntAct: EBI-24661822; Score: 0.56
DE  Interaction: Q9NRX6; IntAct: EBI-24671223; Score: 0.56
DE  Interaction: Q6ZVE7; IntAct: EBI-24734954; Score: 0.56
DE  Interaction: Q9NQQ7; IntAct: EBI-25280941; Score: 0.56
DE  Interaction: O95870; IntAct: EBI-25286406; Score: 0.56
DE  Interaction: Q9NUH8; IntAct: EBI-25288560; Score: 0.56
DE  Interaction: Q8N9Q2; IntAct: EBI-24578171; Score: 0.56
DE  Interaction: Q8N9E0; IntAct: EBI-24636212; Score: 0.56
DE  Interaction: Q9Y320; IntAct: EBI-24646805; Score: 0.56
DE  Interaction: Q8NBQ5; IntAct: EBI-24791121; Score: 0.56
DE  Interaction: Q7Z5P4; IntAct: EBI-25204894; Score: 0.56
DE  Interaction: Q5SR56; IntAct: EBI-25266380; Score: 0.56
DE  Interaction: Q15155; IntAct: EBI-11914340; Score: 0.00
DE  Interaction: Q969V3; IntAct: EBI-11925952; Score: 0.00
DE  Interaction: Q9H1A3; IntAct: EBI-11931217; Score: 0.00
DE  Interaction: Q9NXU5; IntAct: EBI-11933987; Score: 0.00
DE  Interaction: Q9NRX5; IntAct: EBI-11933969; Score: 0.00
DE  Interaction: P30825; IntAct: EBI-21505748; Score: 0.35
DE  Interaction: Q9GZM5; IntAct: EBI-21509346; Score: 0.35
DE  Interaction: Q96FV3; IntAct: EBI-21591007; Score: 0.35
DE  Interaction: Q96KG9; IntAct: EBI-21614942; Score: 0.35
DE  Interaction: P11142; IntAct: EBI-21614942; Score: 0.35
DE  Interaction: O75674; IntAct: EBI-21614942; Score: 0.35
DE  Interaction: B7ZAQ6; IntAct: EBI-21614942; Score: 0.35
DE  Interaction: Q9H2J7; IntAct: EBI-21614809; Score: 0.35
DE  Interaction: P62079; IntAct: EBI-21619035; Score: 0.35
DE  Interaction: Q15884; IntAct: EBI-21620222; Score: 0.35
DE  Interaction: Q9Y2T5; IntAct: EBI-21760939; Score: 0.35
DE  Interaction: O43731; IntAct: EBI-21830599; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-25687199; Score: 0.35
GO  GO:0012505;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0005886;
GO  GO:0003841;
GO  GO:0016746;
GO  GO:0016024;
GO  GO:0006654;
GO  GO:0008654;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGLLAFLKTQFVLHLLVGFVFVVSGLVINFVQLCTLALWPVSKQLYRRLNCRLAYSLWSQLVMLLEWWSCTECTLFTDQA
SQ  TVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIVFCKRKWEEDRDTVVEGLR
SQ  RLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTVAAVYDVTLNFRGNKNPSL
SQ  LGILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKGMFPGEQFKPARRPWTLLNFLSWATILLS
SQ  PLFSFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTEIEKGSSYGNQEFKKKE
//